Results 91 to 100 of about 115,118 (303)

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

Method for determining in vivo antielastasy activity and effectiveness of treatmental and prophylaxis drugs

Journal of Education, Health and Sport
Aim. A method for determining in vivo antielastase activity in rat bone tissue after stress has been proposed. Methods. Stress was reproduced in rats by exposing the animals to −20 °C for 30 minutes.
A. Levitsky, V. Malinovskii, K. Pavlenko, Ya. Yuzkiv, I. Selivanska, A. Lapinska   +5 more
doaj   +1 more source

Alpha-1 antitrypsin is markedly decreased following pulmonary F. tularensis challenge

Frontiers in Cellular and Infection Microbiology, 2011
Alpha-1 antitrypsin, a small glycoprotein clade A serpine serine protease inhibitor of neutrophil elastase has been shown to increase in humans following bacterial and viral infection.
James Patrick Chambers, James Patrick Chambers, Jieh-Juen eYu, Jieh-Juen eYu, Madhulika eJupelli, Susan T Weintraub, Jose L Lopez-Ribot, Jose L Lopez-Ribot, James J. Valdes, Bernard P. Arulanandam, Bernard P. Arulanandam   +10 more
doaj   +1 more source

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elastase Activity, Triggers Wrinkling and Sagging

International Journal of Molecular Sciences, 2015
The repetitive exposure of skin to ultraviolet B (UVB) preferentially elicits wrinkling while ultraviolet A (UVA) predominantly elicits sagging. In chronically UVB or UVA-exposed rat skin there is a similar tortuous deformation of elastic fibers together
G. Imokawa, K. Ishida
semanticscholar   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Binding Structure of Elastase Inhibitor Scyptolin A [PDF]

, 2003
Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic ...
Schulz, Georg E, Weckesser, Jürgen, Jelakovic, Stjepan, Matern, Ute, Schleberger, Christian   +4 more
core   +1 more source

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain*

Journal of Biological Chemistry, 2015
Background: Proteases cleave protease-activated receptor-2 (PAR2), which activates transient receptor potential (TRP) ion channels to cause inflammation and pain.
Pei-Shen Zhao, T. Lieu, N. Barlow, Silvia Sostegni, S. Haerteis, C. Korbmacher, W. Liedtke, N. Jiménez-Vargas, S. Vanner, N. Bunnett   +9 more
semanticscholar   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

Menelloides C and D, New Sesquiterpenoids from the Gorgonian Coral Menella sp.

Marine Drugs, 2011
Two new metabolites, including a lindenane-type sesquiterpenoid, menelloide C (1), and a germacrane-type sesquiterpenoid, menelloide D (2), were isolated from a Formosan gorgonian coral identified as Menella sp. The structures of 1 and 2 were established
Zhi-Hong Wen, Jyh-Horng Sheu, Ping-Jyun Sung, Yang-Chang Wu, Jui-Hsin Su, Tsong-Long Hwang, Shih-Yao Kao   +6 more
doaj   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source