A highly-sensitive genetically encoded temperature indicator exploiting a temperature-responsive elastin-like polypeptide [PDF]
Scientific Reports, 2021 Genetically encoded temperature indicators (GETIs) allow for real-time measurement of subcellular temperature dynamics in live cells. However, GETIs have suffered from poor temperature sensitivity, which may not be sufficient to resolve small heat ...
Cong Quang Vu +3 more
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Development of elastin-like polypeptide for targeted specific gene delivery in vivo [PDF]
Journal of Nanobiotechnology, 2020 Background The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for
Aena Yi +4 more
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Streamlining recombinant peptide and protein production using a pre-configured elastin-like polypeptide expression cassette. [PDF]
PLoS ONEElastin-like polypeptides (ELPs) are synthetic biopolymers that exhibit a unique thermo-responsive behavior: they remain soluble below a defined transition temperature but undergo reversible aggregation when the temperature exceeds this threshold.
Jetson Lobos +2 more
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Investigation of characteristics as endodontic sealer of novel experimental elastin-like polypeptide-based mineral trioxide aggregate [PDF]
Scientific Reports, 2021 Although mineral trioxide aggregates (MTA) have been adopted as an endodontic sealer because of excellent sealing effect and bioactive property and been modified with improvement of its characteristics, the developed MTA sealers have not yet satisfied ...
Hyun-Jung Kim +2 more
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Targeted paclitaxel delivery in ovarian cancer via AP1-functionalized elastin-like polypeptide nanocarriers: development and characterization [PDF]
BMC CancerPaclitaxel has been a cornerstone of ovarian cancer chemotherapy for over two decades. However, its clinical application is constrained by poor solubility and non-specific delivery, resulting in systemic toxicity and inconsistent therapeutic outcomes ...
Ridhima Goel +6 more
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An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]
Scientific ReportsThe tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton +6 more
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Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. [PDF]
PLoS ONE, 2013 Various human solid tumors highly express IL-4 receptors which amplify the expression of some of anti-apoptotic proteins, preventing drug-induced cancer cell death. Thus, IL-4 receptor targeted drug delivery can possibly increase the therapeutic efficacy
Vijaya Sarangthem +8 more
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Journal of Nanobiotechnology, 2023 Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials.
Yingshu Guo +4 more
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Advanced Science, 2021 Design of reversible organelle‐like microcompartments formed by liquid–liquid phase separation in cell‐mimicking entities has significantly advanced the bottom‐up construction of artificial eukaryotic cells.
Hang Zhao +5 more
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Induction of protein body formation in plant leaves by elastin-like polypeptide fusions
BMC Biology, 2009 Background Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins.
Joensuu Jussi J +3 more
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