Results 31 to 40 of about 6,297 (122)

Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies

Advanced Science, 2023
L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high immunogenicity, severe toxicity, short half‐life, and poor stability, restrict its ...
Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao   +4 more
doaj   +1 more source

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Frontiers in Pharmacology, 2023
Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang, Xinqiang Guan, Lianping He, Xingang Guan, Xingang Guan   +4 more
doaj   +1 more source

Facile Synthesis of Peptide-Conjugated Gold Nanoclusters with Different Lengths

Nanomaterials, 2021
The synthesis of ultra-small gold nanoclusters (Au NCs) with sizes down to 2 nm has received increasing interest due to their unique optical and electronic properties.
Qun Ma, Lichao Liu, Zeyue Yang, Peng Zheng   +3 more
doaj   +1 more source

Compositionally Engineered Carboxymethyl Cellulose‐Based Optical Fibers With Exceptionally Low Optical Loss and Quantitative Humidity Sensing

Advanced Physics Research, EarlyView.
Carboxymethyl cellulose‐based biopolymer optical fibers are fabricated using aqueous wet spinning. The fibers exhibit record‐low optical attenuation in polysaccharide‐based waveguides while maintaining efficient transmission across the visible‐to‐near‐infrared region of the electromagnetic spectrum.
Jani Patrakka, Alizee Sanouillet, Ville Hynninen, Nonappa   +3 more
wiley   +1 more source

Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation

Scientific Reports, 2018
Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour.
Ji-Hyun Jang, Sumi Shin, Hyun-Jung Kim, Jinyoung Jeong, Hyo-Eon Jin, Malav S. Desai, Seung-Wuk Lee, Sun-Young Kim   +7 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Exploiting Phase Partitioning of a Giant Trimeric Fibrous Protein Scaffold to Potentiate Chitinase‐Driven Antifungal Activity

Small, EarlyView.
Cstalk, a giant fibrous protein, selectively partitions into the dextran‐rich phase in polyethylene glycol/dextran aqueous two‐phase systems, functioning as a recruiter for proteins of interest. This phase‐selective recruitment can be extended to fungal cell walls, enabling the targeted localization of enzymes and enhancing antifungal activity through ...
Ayasa Nagatani, Shogo Yoshimoto, Toki Taira, Rie Wakabayashi, Masahiro Goto, Katsutoshi Hori, Noriho Kamiya   +6 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Design and Immunogenicity of a Nanoparticle Combination Vaccine for Salmonella in Poultry

Plant Biotechnology Journal, EarlyView.
ABSTRACT Salmonella enterica serovars (Salmonella) are common causes of bacterial gastroenteritis (salmonellosis) often associated with the consumption of poultry products. The control of Salmonella in broiler chickens is difficult because colonized birds may carry this pathogen undetected into the slaughterhouse and cause meat contamination.
Shabnam Shamriz, Angelo Kaldis, Carly A. Charron, Jordan T. VanderBurgt, Christopher P. Garnham, Moussa S. Diarra, Rima Menassa   +6 more
wiley   +1 more source