Results 51 to 60 of about 6,297 (122)

Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

Drug Design, Development and Therapy, 2016
Jeremy WD McGowan,1 Qingmei Shao,1 Parminder JS Vig,1,2 Gene L Bidwell III1,2 1Department of Neurology, 2Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA Abstract: Bypassing the blood–brain barrier is one of ...
McGowan JWD, Shao Q, Vig PJS, Bidwell III GL   +3 more
doaj  

Key Molecular Parameters of PEI for Efficient DNA Delivery Into HEK293T Cells

Macromolecular Chemistry and Physics, Volume 227, Issue 18, 29 September 2026.
Graphical representation of the formation and organization of PEI/eGPF‐C3 polyplexes and their relationship with intracellular plasmid accumulation and transfection efficiency in HEK293T cells. The data suggest that the hierarchical organization of b‐PEI25 polyplexes may contribute to enhanced intracellular plasmid accumulation and gene expression ...
Paulina Alejandra Montaño González, Manon Rochedy, Christophe Schatz, Jean‐Paul Chapel, Ma. Lizbeth Zepeda García, Alberto Gutiérrez Becerra, Sylvain Tranchimand, Patricia Leroyer, Fabienne Gauffre, Soizic Chevance, Pascal Loyer, Lourdes Mónica Bravo Anaya   +11 more
wiley   +1 more source

Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae

Journal of Nanobiotechnology
The overuse of antibiotics and the continuous evolution of drug-resistant bacteria present substantial obstacles to the clinical treatment of Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections.
Meiling Zhou, Yuming Yao, Shuo Ma, Yaya Chen, GuliNazhaer Abudushalamu, Dawen Chen, Xiao Li, Yan Tao, Yue Hou, Xun Gao, Fengfeng Zhao, Chen Zhang, Hua Shao, Guoqiu Wu   +13 more
doaj   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, Volume 22, Issue 52, 16 September 2026.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Rational Design and One-Step Immobilization of Chitosanase for Specific and Recyclable Chitobiose Production

Foods
Chitosan oligosaccharides (COSs) with defined degrees of polymerization (DP) exhibit distinct bioactivities with promising applications in food, pharmaceutical, and agricultural industries. However, the specific and sustainable production of COSs remains
Dandan Tang, Jie Zhang, Na Li, Rui Long, Xinyu Wang, Xiaowen Wang, Wei Liu   +6 more
doaj   +1 more source

A stretchable, electroconductive tissue adhesive for the treatment of neural injury

Bioengineering & Translational Medicine
Successful nerve repair using bioadhesive hydrogels demands minimizing tissue–material interfacial mechanical mismatch to reduce immune responses and scar tissue formation.
Jharana Dhal, Mahsa Ghovvati, Avijit Baidya, Ronak Afshari, Curtis L. Cetrulo Jr, Reza Abdi, Nasim Annabi   +6 more
doaj   +1 more source

Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses

Pharmaceutics, 2019
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye.
Wan Wang, Changrim Lee, Martha Pastuszka, Gordon W. Laurie, J. Andrew MacKay   +4 more
doaj   +1 more source

Material engineering and application of hybrid biomimetic-de novo designed elastin-like polypeptides

Communications Materials
The global concern over environmental consequences of petrochemical-derived plastics underscores the urgent need for sustainable and biodegradable polymers.
Zhuoran Geng, Timo Laakko, Ari Hokkanen, Caj Södergård, Ilari Maasilta, Pezhman Mohammadi   +5 more
doaj   +1 more source