Results 61 to 70 of about 6,297 (122)

Intracellular Delivery of a p21-Derived Cell Cycle Inhibitory Peptide Using Elastin-like Polypeptides Suppresses Glioblastoma Cell Proliferation

Molecules
Glioblastoma, with a 5-year survival rate of just under 7.0%, is the most common form of brain cancer in adults. In this study, we evaluated the antiproliferative activity of the biopolymer p21-ELP1-Bac, a p21-derived peptide delivered via an elastin ...
Tiffany Quinn, Yumnaa Shaheen, Drazen Raucher   +2 more
doaj   +1 more source

Injectable thixotropic hydrogel composed of elastin-like polypeptide and oxidized dextran for anastomotic support

NPG Asia Materials
Anastomotic leakage remains a serious complication in gastrointestinal surgery, with unsatisfactory improvement in incidence over recent decades. Conventional sealants, such as fibrin glue, require intraoperative mixing and offer limited ease of handling.
Yuki Aoyama, Yuta Nakano, Takahiro Shinozuka, Kotaro Aoki, Kazumasa Suzuki, Chikara Ohtsuki, Mitsuro Kanda, Ayae Sugawara-Narutaki   +7 more
doaj   +1 more source

Application of Thermally Responsive Elastin-like Polypeptide Fused to a Lactoferrin-derived Peptide for Treatment of Pancreatic Cancer

Molecules, 2009
A well characterized, peptide derivative of bovine lactoferrin, L12, has been shown to possess anticancer properties in multiple cell lines. However, adverse side effects in normal tissues and poor plasma kinetics that hinder the clinical effectiveness ...
Emily Thomas, Iqbal Massodi, Drazen Raucher   +2 more
doaj   +1 more source

Molecular Size Modulates Pharmacokinetics, Biodistribution, and Renal Deposition of the Drug Delivery Biopolymer Elastin-like Polypeptide

Scientific Reports, 2018
Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics.
Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell   +3 more
doaj   +1 more source

Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer

Drug Design, Development and Therapy, 2014
Leslie R Walker,1 Jung Su Ryu,1 Eddie Perkins,2 Lacey R McNally,3 Drazen Raucher1 1Department of Biochemistry, 2Department of Neurosurgery, University of Mississippi Medical Center, Jackson, MS, USA; 3Division of Hematology and Oncology, University of ...
Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D   +4 more
doaj  

pH-Responsive Elastin-Like Polypeptide Designer Condensates. [PDF]

ACS Appl Mater Interfaces, 2023
de Haas RJ, Ganar KA, Deshpande S, de Vries R.   +3 more
europepmc   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures
Elastin‐like polypeptides (ELPs), genetically programmable biomaterials derived from natural tropoelastin, exhibit unique reversible self‐assembly and aggregation behaviors driven by sequence‐encoded phase transitions.
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
doaj   +1 more source

Robust Photocontrol of Elastin-like Polypeptide Phase Transition with a Genetically Encoded Arylazopyrazole. [PDF]

ACS Synth Biol, 2023
Strugach DS, Hadar D, Amiram M.
europepmc   +1 more source

Application of Elastin-like Polypeptide in Tumor Therapy. [PDF]

Cancers (Basel), 2022
Shi X, Chen D, Liu G, Zhang H, Wang X, Wu Z, Wu Y, Yu F, Xu Q.   +8 more
europepmc   +1 more source

Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke. [PDF]

FASEB J, 2023
Howell JA, Gaouette N, Lopez M, Burke SP, Perkins E, Bidwell GL.   +5 more
europepmc   +1 more source