Results 51 to 60 of about 36,056 (184)
Molecules, 2022 The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic +3 more
doaj +1 more source
Induction of protein body formation in plant leaves by elastin-like polypeptide fusions
BMC Biology, 2009 Background Elastin-like polypeptides are synthetic biopolymers composed of a repeating pentapeptide 'VPGXG' sequence that are valuable for the simple non-chromatographic purification of recombinant proteins.
Joensuu Jussi J +3 more
doaj +1 more source
The liquid structure of elastin
eLife, 2017 The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation ...
Sarah Rauscher, Régis Pomès
doaj +1 more source
BioTechniques, 2016 The protocol described here is designed as an extension of existing techniques for creating elastin-like polypeptides. It allows for the expression and purification of elastin-like polypeptide (ELP) constructs that are poorly expressed or have very low ...
Markian S. Bahniuk +2 more
doaj +1 more source
The application of elastin-like peptides in cancer, tissue engineering and ocular disease
OpenNano, 2023 Elastin-like polypeptides (ELPs) are macromolecular biopolymers composed of natural amino acids. ELPs can be prepared by genetic engineering so that their amino acid sequences and molecular weight can be precisely manipulated.
Dabo Jiang +7 more
doaj +1 more source
Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement [PDF]
ACS Applied Materials & Interfaces, 2018 Artificial multiprotein complexes are sought after reagents for biomolecular engineering. A current limiting factor is the paucity of molecular scaffolds which allow for site-specific multicomponent assembly. Here, we address this limitation by synthesizing bioorthogonal elastin-like polypeptide (ELP) scaffolds containing periodic noncanonical l ...
Duy Tien Ta +2 more
openaire +4 more sources
Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma
Molecules, 2019 To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors.
Sonja Dragojevic +2 more
doaj +1 more source
Elastin‐like polypeptides as models of intrinsically disordered proteins [PDF]
FEBS Letters, 2015 Elastin‐like polypeptides (ELPs) are a class of stimuli‐responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has ...
Roberts, Stefan +2 more
openaire +2 more sources
Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins [PDF]
, 2012 Elastin-like polypeptides (ELPs) are a class of stimulus-responsive biopolymers whose physicochemical properties and biocompatibility are particularly suitable for in vivo applications, such as drug delivery and tissue engineering. The lower critical solution temperature (LCST) behavior of ELPs allows them to be utilized as soluble macromolecules below
Wafa, Hassouneh +2 more
openaire +2 more sources
Sequence‐Modulated Active Tripeptide Condensates for Tandem Catalysis
Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.Sequence‐modulated tripeptide coacervates mimic biomolecular condensates with controllable, enzyme‐regulated phase separation. They co‐sequester hydrophobic active species and hydrophilic enzymes, enabling tandem catalysis in aqueous media. Incorporated into artificial cells, they function as adaptive sub‐organelles, orchestrating compartmentalized ...
Hao Han +7 more
wiley +2 more sources