Results 41 to 50 of about 113,337 (338)

Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling [PDF]

open access: yes, 2015
BACKGROUND: During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin.
Diefenbach, Claudia   +7 more
core   +1 more source

Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human

open access: yesCells, 2023
Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying ...
Soumya Navneet   +3 more
doaj   +1 more source

Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture [PDF]

open access: yes, 2015
Background: Thoracic aortic rupture and aortopulmonary fistulation are rare conditions in horses. It mainly affects Friesian horses. Intrinsic differences in biomechanical properties of the aortic wall might predispose this breed.
Chiers, Koen   +10 more
core   +2 more sources

Elastin‐Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Thoracic aortic aneurysm (TAA) and dissection (TAD) are characterized by progressive disorganization of the aortic wall matrix, including elastin, a highly immunogenic molecule.
Bon‐Hee Gu   +11 more
doaj   +1 more source

In vivo endoscopic autofluorescence microspectro-imaging of bronchi and alveoli [PDF]

open access: yes, 2008
Fibered confocal fluorescence microscopy (FCFM) is a new technique that can be used during a bronchoscopy to analyze the nature of the human bronchial and alveolar mucosa fluorescence microstructure. An endoscopic fibered confocal fluorescence microscopy
Bourg-Heckly, G.   +3 more
core   +2 more sources

Elastin degradation products in acute lung injury induced by gastric contents aspiration

open access: yesRespiratory Research, 2018
Background Gastric contents aspiration is a high-risk condition for acute lung injury (ALI). Consequences range from subclinical pneumonitis to respiratory failure, depending on the volume of aspirate.
Pedro Ayala   +5 more
doaj   +1 more source

Characterization of the Zebrafish Elastin a (elnasa12235) Mutant: A New Model of Elastinopathy Leading to Heart Valve Defects

open access: yesCells, 2023
Elastic fibers are extracellular macromolecules that provide resilience and elastic recoil to elastic tissues and organs in vertebrates. They are composed of an elastin core surrounded by a mantle of fibrillin-rich microfibrils and are essentially ...
Marie Hoareau   +3 more
doaj   +1 more source

Temperature Dependent Conformational Transitions and Hydrogen Bond Dynamics of the Elastin-Like Octapeptide GVG(VPGVG): a Molecular Dynamics Study [PDF]

open access: yes, 2004
A joint experimental / theoretical investigation of the elastin-like octapeptide GVG(VPGVG) was carried out. In this paper a comprehensive molecular dynamics study of the temperature dependent folding and unfolding of the octapeptide is presented.
Aalten   +62 more
core   +2 more sources

PKCε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: In the earlier study, the selective PKCε activator DCP-LA increased elastic fibres in the dermis of HR-1 hairless mice. As a process of elastic fibre formation, tropoelastin, an elastin monomer, is secreted into the extracellular space ...
Tomoyuki Nishizaki
doaj   +1 more source

Time-sequential fibroblast-to-myofibroblast transition in elastin-variable 3D hydrogel environments by collagen networks

open access: yesBiomaterials Research, 2023
Background Fibrosis plays an important role in both normal physiological and pathological phenomena as fibroblasts differentiate to myofibroblasts. The activation of fibroblasts is determined through interactions with the surrounding extracellular matrix
Nhuan T. Do   +7 more
doaj   +1 more source

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