TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]
, 2017 Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc +12 more
core +2 more sources
Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. [PDF]
, 2020 Platelets are a recognised potent source of transforming growth factor-β1 (TGFβ1), a cytokine known to promote wound healing and regeneration by stimulating dermal fibroblast proliferation and extracellular matrix deposition.
Chong, DLW +7 more
core +3 more sources
New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]
, 1984 The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter +3 more
core +1 more source
Mechanical Properties and Functions of Elastin: An Overview
Biomolecules, 2023 Human tissues must be elastic, much like other materials that work under continuous loads without losing functionality. The elasticity of tissues is provided by elastin, a unique protein of the extracellular matrix (ECM) of mammals.
Hanna Trębacz, Angelika Barzycka
doaj +1 more source
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core +2 more sources
Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1 [PDF]
, 2020 Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Boyle, Walter A +7 more
core +3 more sources
The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes [PDF]
, 2016 © 2016 Elsevier Inc. Background Arteriovenous fistulae (AVFs) are the preferred access for hemodialysis but suffer a high early failure rate. The aim of this study was to determine how venous distensibility, as measured in vitro, relates to early ...
Barnes, Rachel +4 more
core +1 more source
Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
Frontiers in Cell and Developmental Biology, 2021 As the primary component of elastic fibers, elastin plays an important role in maintaining the elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and organs.
Keke Wang +3 more
doaj +1 more source
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]
, 2015 Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core +1 more source
Protein-based materials, toward a new level of structural control [PDF]
, 2001 Through billions of years of evolution nature has created and refined structural proteins for a wide variety of specific purposes. Amino acid sequences and their associated folding patterns combine to create elastic, rigid or tough materials.
Tirrell, David A., van Hest, Jan C. M.
core +1 more source