Results 201 to 210 of about 2,460,746 (279)

3dcon: tomogram denoising by deconvolution. [PDF]

Acta Crystallogr D Struct Biol
Kirchweger P, Melnikovsky L, Seifer S, Elbaum M.   +3 more
europepmc   +1 more source

Self‐Assembled Macrocyclic Nanocarriers for Rapid Ratiometric Loading and Dosing of Multidrug Combinations

Angewandte Chemie, EarlyView.
This work presents a thermodynamically programmable nanoplatform based on calixarenes that enables precise, tunable drug loading and release with broad applicability. Across diverse drugs and ratios, both loading and delivery matched preset values with > 95% accuracy in cells and tumors.
Yu‐Chen Pan, Yuan‐Qiu Cheng, Shao‐Qing Fan, Shu‐Xin Zhang, Ze‐Han Wang, Jie Chen, Zhilin Yu, Fang‐Yuan Chen, Werner M. Nau, Dong‐Sheng Guo   +9 more
wiley   +2 more sources

AI-assisted Cryo-ET workflow for 3D visualization of chromatin during cellular differentiation. [PDF]

Biochem Biophys Rep
Watt J, Roth C, Huber I, Hall AS, Singh MK, Micheva-Viteva S, Sanbonmatsu KY, Starkenburg SR, Steadman CR.   +8 more
europepmc   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

Arctis WebUI redefines lamella preparation for cryo-electron tomography workflow [PDF]

BIO Web of Conferences
Vrbovská Veronika, Spurný Radovan, Kříž Radim, Tichý Radek, Tomášek Pavel, Chvíla Ladislav, Müllerová Michaela, Kasáková Anna, Mitchels John, Hovorka Miloš   +9 more
doaj   +1 more source

Molecular Packaging, Liquid-Crystalline Order, and Three-Dimensional Architecture of Dinoflagellate Chromosomes. [PDF]

J Microbiol Biotechnol
Chung JM, Suzaki T, Fukuda Y, Song C.
europepmc   +1 more source

Direct Observation of Radical‐Mediated Oxide‐to‐Alloy Transformation in Solution Under Pulsed Laser Irradiation

Angewandte Chemie, EarlyView.
Time‐resolved in situ x‐ray absorption spectroscopy and DFTB‐based molecular dynamics simulations identify direct hydrogen atom transfer from ethanol to lattice oxygen as the elementary step of laser‐driven reduction in NiCo2O4. While this transfer is facile, the subsequent release of lattice oxygen is entropy‐driven and becomes accessible only at ...
Woo Hyeok Kim, Sieon Jung, Ahreum Min, Raja Arumugam Senthil, Juhyeon Park, Wonil Seo, Seung Yeon Choi, Junu Bae, Cheolhee Yang, In‐hui Hwang, Joonghan Kim, Tae Wu Kim, Myong Yong Choi   +12 more
wiley   +2 more sources

Acoustofluidic cryo-EM enables in situ particle manipulation for uniform, high-quality cryo-EM specimens. [PDF]

Sci Adv
Yang K, Peele W, Liu P, Xia J, Dandey V, Zhong R, Jin K, Sharma K, Watson AJ, Yang S, Chen Y, Agahtehrani A, Lan SN, Zhang P, Tian Z, Liu M, Viverette E, Xu X, Wu Q, Borgnia MJ, Lee LP, Huang TJ.   +21 more
europepmc   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources