Results 31 to 40 of about 10,979,485 (217)

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

Cell Reports, 2016
Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ)
Adela Guarás, Ester Perales-Clemente, Enrique Calvo, Rebeca Acín-Pérez, Marta Loureiro-Lopez, Claire Pujol, Isabel Martínez-Carrascoso, Estefanía Nuñez, Fernando García-Marqués, María Angeles Rodríguez-Hernández, Ana Cortés, Francisca Diaz, Acisclo Pérez-Martos, Carlos T. Moraes, Patricio Fernández-Silva, Aleksandra Trifunovic, Plácido Navas, Jesús Vazquez, Jose A. Enríquez   +18 more
doaj   +1 more source

Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I

PLoS ONE, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions. Its mode of action was proposed to involve inhibition of increased GRP78 (glucose regulated protein 78) expression during hypoglycemia. Because GRP78 plays an
Thomas, Simmy, Sharma, Natasha, Gonzalez, Reyna, Pao, Peng-Wen, Hofman, Florence M, Chen, Thomas C, Louie, Stan G, Pirrung, Michael C, Schönthal, Axel H   +8 more
openaire   +6 more sources

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes

Frontiers in Medicine, 2020
Background: Hepatic dysfunction plays a major role in adverse outcomes in sepsis. Volatile anesthetic agents may protect against organ dysfunction in the setting of critical illness and infection.
Hari Prasad Osuru, Umadevi Paila, Keita Ikeda, Zhiyi Zuo, Robert H. Thiele   +4 more
doaj   +1 more source

Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I) [PDF]

, 2010
NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme in the mitochondrial electron transfer chain. It catalyses the oxidation of NADH and the reduction of ubiquinone, coupled to the translocation of protons across the ...

core   +2 more sources

Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle. [PDF]

PLoS ONE, 2013
Mitochondrial oxidative stress is a complex phenomenon that is inherently tied to energy provision and is implicated in many metabolic disorders. Exercise training increases mitochondrial oxidative capacity in skeletal muscle yet it remains unclear if ...
Justin D Crane, Arkan Abadi, Bart P Hettinga, Daniel I Ogborn, Lauren G MacNeil, Gregory R Steinberg, Mark A Tarnopolsky   +6 more
doaj   +1 more source

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Biology, 2020
The most famous role of mitochondria is to generate ATP through oxidative phosphorylation, a metabolic pathway that involves a chain of four protein complexes (the electron transport chain, ETC) that generates a proton-motive force that in turn drives ...
Sílvia C. Rodrigues, Renato M. S. Cardoso, Filipe V. Duarte   +2 more
doaj   +1 more source

Suppression of mitochondrial complex I influences cell metastatic properties. [PDF]

PLoS ONE, 2013
Despite the fact that mitochondrial dysfunction has an important role in tumorigenesis and metastasis, the underlying mechanism remains to be elucidated.
Xuelian He, Aifen Zhou, Hao Lu, Yong Chen, Guochang Huang, Xin Yue, Peiwei Zhao, Yanxiang Wu   +7 more
doaj   +1 more source

Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or hypertension, leading to heart failure and increased risk for death in diabetic patients.
Karina P. Gomes, Karina P. Gomes, Anshul S. Jadli, Anshul S. Jadli, Luiz G. N. de Almeida, Luiz G. N. de Almeida, Noura N. Ballasy, Noura N. Ballasy, Pariya Edalat, Pariya Edalat, Ruchita Shandilya, Ruchita Shandilya, Daniel Young, Daniel Young, Darrell Belke, Darrell Belke, Jane Shearer, Jane Shearer, Antoine Dufour, Antoine Dufour, Antoine Dufour, Antoine Dufour, Vaibhav B. Patel, Vaibhav B. Patel   +23 more
doaj   +1 more source

Proteomic strategy for the analysis of the polychlorobiphenyl-degrading cyanobacterium Anabaena PD-1 exposed to Aroclor 1254.

PLoS ONE, 2014
The cyanobacterium Anabaena PD-1, which was originally isolated from polychlorobiphenyl (PCB)-contaminated paddy soils, has capabilities for dechlorinatin and for degrading the commercial PCB mixture Aroclor 1254.
Hangjun Zhang, Xiaojun Jiang, Wenfeng Xiao, Liping Lu   +3 more
doaj   +1 more source