Results 11 to 20 of about 155,865 (232)

Deletion of Von Willebrand A Domain Containing Protein (VWA8) raises activity of mitochondrial electron transport chain complexes in hepatocytes

Biochemistry and Biophysics Reports, 2021
VWA8 (Von Willebrand A Domain Containing Protein 8) is a AAA+ ATPase that is localized to the mitochondrial matrix and is widely expressed in highly energetic tissues. Originally found to be higher in abundance in livers of mice fed a high fat diet, deletion of the VWA8 gene in differentiated mouse AML12 hepatocytes unexpectedly produced a phenotype of
Moulun Luo, Wuqiong Ma, Rocio Zapata-Bustos, Wayne T. Willis, Lawrence J. Mandarino   +4 more
openaire   +3 more sources

Chemical and Genetic Modulation of Complex I of the Electron Transport Chain Enhances the Biotherapeutic Protein Production Capacity of CHO Cells

Cells, 2023
Chinese hamster ovary (CHO) cells are the cell line of choice for producing recombinant therapeutic proteins. Despite improvements in production processes, reducing manufacturing costs remains a key driver in the search for more productive clones.
Corey Kretzmer, Kelsey Reger, Vincent Balassi, Quang Long Pham, Michael Johns, Samuel T. Peters, Amber Petersen, Jana Mahadevan, Jason Gustin, Trissa Borgschulte, David Razafsky   +10 more
openaire   +3 more sources

RESEARCH The effect of gestational age on mitochondrial properties of the mouse placenta

Reproduction and Fertility, 2022
Mitochondria are organelles within the cell that generate energy, which is essential to the developing placenta. As the placenta approaches term, organelles such as mitochondria and the endoplasmic reticulum adapt to cellular stressors (e.g.
Lucy A Bartho, Joshua J Fisher, Sarah L Walton, Anthony V Perkins, James S M Cuffe   +4 more
doaj   +1 more source

The Role of Mitochondrial Dysfunction in the Development of Acute and Chronic Hepatitis С

Frontiers in Bioscience-Scholar, 2023
Currently, the issue relating to the discussion raised in this article appears to be for what purposes the hepatitis C virus (HCV) modulates cellular processes, such as antiviral defense, metabolism, apoptosis, and mitochondrial dynamics, by inhibiting ...
Alexander Blagov, Vasily Sukhorukov, Varvara Orekhova, Anton Postnov, Mikhail Popov, Alexander Orekhov   +5 more
doaj   +1 more source

Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways

Clinical and Translational Medicine, 2022
Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific areas of the ...
Yura Jang, Thujitha Thuraisamy, Javier Redding‐Ochoa, Olga Pletnikova, Juan C. Troncoso, Zhen Zhang, Liana S. Rosenthal, Ted M. Dawson, Alexander Y. Pantelyat, Chan Hyun Na   +9 more
doaj   +1 more source

The Cpx Stress Response Regulates Turnover of Respiratory Chain Proteins at the Inner Membrane of Escherichia coli

Frontiers in Microbiology, 2022
The Cpx envelope stress response is a major signaling pathway monitoring bacterial envelope integrity, activated both internally by excessive synthesis of membrane proteins and externally by a variety of environmental cues.
Valeria Tsviklist, Randi L. Guest, Tracy L. Raivio   +2 more
doaj   +1 more source

Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly

Pulmonary Circulation, 2020
Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O 2 max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexes are
Danielle J. McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T. Clements, Gaurav Choudhary   +5 more
doaj   +1 more source

Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G‐αB‐Crystallin‐Induced Desmin‐Related Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The mutated α‐B‐Crystallin (CryABR120G) mouse model of desmin‐related myopathy (DRM) shows an age‐dependent onset of pathologic cardiac remodeling and progression of heart failure.
Shafiul Alam, Chowdhury S. Abdullah, Richa Aishwarya, Mahboob Morshed, Sadia S. Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan   +9 more
doaj   +1 more source

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

Open Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska   +2 more
doaj   +1 more source

Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells

Data in Brief, 2022
Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. An unbiased analysis of proteomes of parental MDA-MB-231 breast cancer cells and two separate NAT1 knockout (KO) cell lines were performed. Among 4,890 proteins identified,
Kyung U. Hong, Jonathan Q. Gardner, Mark A. Doll, Marcus W. Stepp, Daniel W. Wilkey, Frederick W. Benz, Jian Cai, Michael L. Merchant, David W. Hein   +8 more
doaj   +1 more source