Results 1 to 10 of about 155,766 (133)

Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes [PDF]

Free Radical Biology and Medicine, 2008
Mitochondrially generated ROS increase with age and are a major factor that damages proteins by oxidative modification. Accumulation of oxidatively damaged proteins has been implicated as a causal factor in the age-associated decline in tissue function.
Kashyap B, Choksi, John, Papaconstantinou   +1 more
openaire   +4 more sources

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chin-Hsien Lin, Chih-Chiang Chan   +9 more
doaj   +3 more sources

Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes [PDF]

Free Radical Biology and Medicine, 2008
Age-associated mitochondrial dysfunction is a major source of reactive oxygen species (ROS) and oxidative modification to proteins. Mitochondrial electron transport chain (ETC) complexes I and III are the sites of ROS production and we hypothesize that proteins of the ETC complexes are primary targets of ROS-mediated modification which impairs their ...
Kashyap B, Choksi, Jonathan E, Nuss, James H, Deford, John, Papaconstantinou   +3 more
openaire   +4 more sources

Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis

Mitochondrion, 2020
We identified Coxfa4l3, previously called C15orf48 or Nmes1, as a novel accessory protein of Complex IV of the mitochondrial electron transport chain (ETC). Amino acid sequence comparison, the intracellular localization and the protein expression data showed that the protein is the third isoform of Coxfa4 and the expression of Coxfa4 and Coxfa4l3 ...
Masahiro, Endou, Kaito, Yoshida, Makoto, Hirota, Chika, Nakajima, Atsumi, Sakaguchi, Naoto, Komatsubara, Yasuyuki, Kurihara   +6 more
openaire   +4 more sources

Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes [PDF]

Free Radical Biology and Medicine, 2007
Mitochondrial dysfunction generates reactive oxygen species (ROS) which damage essential macromolecules. Oxidative modification of proteins, DNA, and lipids has been implicated as a major causal factor in the age-associated decline in tissue function. Mitochondrial electron transport chain complexes I and III are the principal sites of ROS production ...
Kashyap B, Choksi, Jonathan E, Nuss, William H, Boylston, Jeffrey P, Rabek, John, Papaconstantinou   +4 more
openaire   +4 more sources

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins.
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +3 more sources

ETMB-RBF: discrimination of metal-binding sites in electron transporters based on RBF networks with PSSM profiles and significant amino acid pairs. [PDF]

PLoS ONE, 2013
BACKGROUND: Cellular respiration is the process by which cells obtain energy from glucose and is a very important biological process in living cell. As cells do cellular respiration, they need a pathway to store and transport electrons, the electron ...
Yu-Yen Ou, Shu-An Chen, Sheng-Cheng Wu
doaj   +1 more source

Palmitic Acid, but Not Lauric Acid, Induces Metabolic Inflammation, Mitochondrial Fragmentation, and a Drop in Mitochondrial Membrane Potential in Human Primary Myotubes

Frontiers in Nutrition, 2021
The chain length of saturated fatty acids may dictate their impact on inflammation and mitochondrial dysfunction, two pivotal players in the pathogenesis of insulin resistance.
Domenico Sergi, Domenico Sergi, Natalie Luscombe-Marsh, Nenad Naumovski, Nenad Naumovski, Mahinda Abeywardena, Nathan O'Callaghan   +6 more
doaj   +1 more source

Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex [PDF]

Journal of Biological Chemistry, 2019
Three mitochondrial metabolic pathways are required for efficient energy production in eukaryotic cells: the electron transfer chain (ETC), fatty acid β-oxidation (FAO), and the tricarboxylic acid cycle. The ETC is organized into inner mitochondrial membrane supercomplexes that promote substrate channeling and catalytic efficiency.
Yudong Wang, Johan Palmfeldt, Niels Gregersen, Alexander M. Makhov, James F. Conway, Meicheng Wang, Stephen P. McCalley, Shrabani Basu, Hana Alharbi, Claudette St. Croix, Michael J. Calderon, Simon Watkins, Jerry Vockley   +12 more
openaire   +3 more sources

Regulation of COX Assembly and Function by Twin CX₉C Proteins—Implications for Human Disease

Cells, 2021
Oxidative phosphorylation is a tightly regulated process in mammals that takes place in and across the inner mitochondrial membrane and consists of the electron transport chain and ATP synthase.
Stephanie Gladyck, Siddhesh Aras, Maik Hüttemann, Lawrence I. Grossman   +3 more
doaj   +1 more source