Results 21 to 30 of about 155,865 (232)

A Chinese Hamster Mutant Cell Line with a Defect in the Integral Membrane Protein CII-3 of Complex II of the Mitochondrial Electron Transport Chain [PDF]

Journal of Biological Chemistry, 1995
In this study, a respiration-deficient Chinese hamster cell line with a defect in succinate dehydrogenase activity is shown to result from a single base change in a codon in the coding sequence for the membrane anchor protein CII-3 (also referred to as QPs-1). A premature translation stop results in the truncation of 33 amino acids from the C terminus.
F G, Oostveen, H C, Au, P J, Meijer, I E, Scheffler   +3 more
openaire   +2 more sources

Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex.

PLoS Pathogens, 2021
The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important pathogens of humans causing diseases such as toxoplasmosis and malaria, depend on ...
Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner   +6 more
doaj   +1 more source

A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training

Proteomes, 2017
We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training ...
Kanchana Srisawat, Sam O. Shepherd, Paulo J. Lisboa, Jatin G. Burniston   +3 more
doaj   +1 more source

Mitochondrial function and Aβ in Alzheimer's disease postmortem brain

Neurobiology of Disease, 2022
Introduction: Mitochondrial dysfunction is observed in Alzheimer's disease (AD). However, the relationship between functional mitochondrial deficits and AD pathologies is not well established in human subjects.
Benjamin R. Troutwine, Taylor A. Strope, Edziu Franczak, Colton R. Lysaker, Laylan Hamid, Clayton Mansel, Julia A. Stopperan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins   +10 more
doaj   +1 more source

Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis [PDF]

Scientific Reports, 2019
AbstractTrophoblast oxidative phosphorylation provides energy for active transport and protein synthesis, which are critical placental functions influencing fetal growth and long-term health. The molecular mechanisms regulating trophoblast mitochondrial oxidative phosphorylation are largely unknown.
Rosario, Fredrick J, Gupta, Madhulika B, Myatt, Leslie, Powell, Theresa L, Glenn, Jeremy P, Cox, Laura, Jansson, Thomas   +6 more
openaire   +4 more sources

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

Cell Reports, 2016
Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ)
Adela Guarás, Ester Perales-Clemente, Enrique Calvo, Rebeca Acín-Pérez, Marta Loureiro-Lopez, Claire Pujol, Isabel Martínez-Carrascoso, Estefanía Nuñez, Fernando García-Marqués, María Angeles Rodríguez-Hernández, Ana Cortés, Francisca Diaz, Acisclo Pérez-Martos, Carlos T. Moraes, Patricio Fernández-Silva, Aleksandra Trifunovic, Plácido Navas, Jesús Vazquez, Jose A. Enríquez   +18 more
doaj   +1 more source

Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I

PLoS ONE, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions. Its mode of action was proposed to involve inhibition of increased GRP78 (glucose regulated protein 78) expression during hypoglycemia. Because GRP78 plays an
Thomas, Simmy, Sharma, Natasha, Gonzalez, Reyna, Pao, Peng-Wen, Hofman, Florence M, Chen, Thomas C, Louie, Stan G, Pirrung, Michael C, Schönthal, Axel H   +8 more
openaire   +6 more sources

Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes

Frontiers in Medicine, 2020
Background: Hepatic dysfunction plays a major role in adverse outcomes in sepsis. Volatile anesthetic agents may protect against organ dysfunction in the setting of critical illness and infection.
Hari Prasad Osuru, Umadevi Paila, Keita Ikeda, Zhiyi Zuo, Robert H. Thiele   +4 more
doaj   +1 more source

Suppression of mitochondrial complex I influences cell metastatic properties. [PDF]

PLoS ONE, 2013
Despite the fact that mitochondrial dysfunction has an important role in tumorigenesis and metastasis, the underlying mechanism remains to be elucidated.
Xuelian He, Aifen Zhou, Hao Lu, Yong Chen, Guochang Huang, Xin Yue, Peiwei Zhao, Yanxiang Wu   +7 more
doaj   +1 more source

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Biology, 2020
The most famous role of mitochondria is to generate ATP through oxidative phosphorylation, a metabolic pathway that involves a chain of four protein complexes (the electron transport chain, ETC) that generates a proton-motive force that in turn drives ...
Sílvia C. Rodrigues, Renato M. S. Cardoso, Filipe V. Duarte   +2 more
doaj   +1 more source