Results 51 to 60 of about 441,339 (185)

6-PPD quinone at environmentally relevant concentrations activates feedback response of electron transport chain to mediate damage on mitochondrial function and longevity in Caenorhabditis elegans

Environmental Chemistry and Ecotoxicology
6-PPD quinone (6-PPDQ) could cause mitochondrial dysfunction; however, response of entire electron transport chain to 6-PPDQ remains largely unclear. In Caenorhabditis elegans, activity of mitochondrial complex IV was inhibited by 6-PPDQ (1–10 μg/L), and
Xin Hua, Dayong Wang
doaj   +1 more source

Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

Scientific Reports, 2022
Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensive. Therefore,
Ashwin Sachdeva, Claire A. Hart, Christopher D. Carey, Amy E. Vincent, Laura C. Greaves, Rakesh Heer, Pedro Oliveira, Michael D. Brown, Noel W. Clarke, Doug M. Turnbull   +9 more
doaj   +1 more source

SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling

Science Advances, 2020
A sulfide oxidase mediates therapeutic actions of H2S by targeting mitochondrial electron flow to induce mitochondrial uncoupling. Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent.
J. Jia, Zichuang Wang, Minjie Zhang, Caiyun Huang, Yanmei Song, Fuyou Xu, Jingyu Zhang, J. Li, Meijun He, Yuyao Li, Guizhen Ao, Chengjiao Hong, Yongjun Cao, Y. Chin, Z. Hua, Jian Cheng   +15 more
semanticscholar   +1 more source

The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1

BMC Microbiology, 2004
Background Shewanella oneidensis MR-1 uses several electron acceptors to support anaerobic respiration including insoluble species such as iron(III) and manganese(IV) oxides, and soluble species such as nitrate, fumarate, dimethylsulfoxide and many ...
Myers Charles R, Maier Tamara M
doaj   +1 more source

Improved Functionality of Poly(3,4-Ethylenedioxythiophene):Poly(Styrenesulfonate)/HeptaCoordinated Organotin Complex Films via Graphene Applied to Organic Solar Cell Fabrications

Frontiers in Materials, 2022
Enhanced transparency, conductivity, and stability are some of the most important factors to consider in order to prepare transparent electrodes (TEs) and hole transport layer (HTL) for organic solar cells.
María Elena Sánchez Vergara, Rafael Imanol Zubillaga Serrano, Leon Hamui, José Miguel Galván Hidalgo, Ismael Cosme, Elizabeth Gómez   +5 more
doaj   +1 more source

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2019
Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and ...
T. Panagaki, Elisa B. Randi, Fiona Augsburger, C. Szabó   +3 more
semanticscholar   +1 more source

Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis

Translational Psychiatry, 2020
Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain were assessed in acute psychosis. Astrocyte-derived exosomes (ADEs) and neuron-derived exosomes (NDEs) were immunoprecipitated from plasma of ten untreated first ...
E. Goetzl, V. Srihari, S. Guloksuz, M. Ferrara, C. Tek, G. Heninger   +5 more
semanticscholar   +1 more source

Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV [PDF]

, 2019
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies.
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, Guerra Castellano, Alejandra, Pérez Mejías, Gonzalo, Rosa Acosta, Miguel Ángel de la   +4 more
core   +1 more source

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

International Journal of Molecular Medicine, 2019
The mammalian mitochondrial electron transport chain (ETC) includes complexes I-IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and ...
Ruzhou Zhao, Shuai Jiang, Lin Zhang, Zhi-Bin Yu   +3 more
semanticscholar   +1 more source

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin.
Stefan Geldon, Erika Fernández-Vizarra, Kostas Tokatlidis   +2 more
doaj   +1 more source