Results 41 to 50 of about 210,369 (310)
Data, 2021 Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem and progenitor cells, which results in the build-up of immature blasts in the bone marrow and eventually in the peripheral blood of affected patients.
Juan E. Urrea +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Puzzle of Proteoform Variety—Where Is a Key?
ProteomesOne of the human proteome puzzles is an imbalance between the theoretically calculated and experimentally measured amounts of proteoforms. Considering the possibility of combinations of different post-translational modifications (PTMs), the quantity of ...
Stanislav Naryzhny
doaj +1 more source
Annals of Hepatology, 2015 Background and rationale. We aimed to provide novel information to better understand the molecular mechanisms underlying gallstones formation and explore the potential protein markers for gallstones progression.
Changlin Qian +4 more
doaj +1 more source
Proteome Analysis of Pyloric Ceca: A Methodology for Fish Feed Development? [PDF]
, 2012 Changing the protein source of fish feed from fish meal to alternative sources of protein will affect traits such as fish growth, quality, and feed utilization.
Jessen, Flemming +4 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Two-dimensional gel electrophoresis data for proteomic profiling of Sporothrix yeast cells
Data in Brief, 2015 Sporotrichosis is a chronic infection of the skin and subcutaneous tissues of human and other mammals caused by a complex of cryptic dimorphic fungi in the plant-associated order Ophiostomatales.
Anderson Messias Rodrigues +5 more
doaj +1 more source
Analysis of the proteome and the secretome of animal trypanosomes : a standardized analytical method to look for new molecular targets [PDF]
, 2007 The causative agents of animal trypanosomosis are various species of protozoan parasites belonging to the genus Trypanosoma, among which T. congolense and T. evansi are the major pathogenic species. The extra cellular position of the trypanosomes implies
Bengaly, Zakaria +10 more
core
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Variation of proteomic profile during lactation in Girgentana goat milk: a preliminary study
Italian Journal of Animal Science, 2019 The knowledge of milk proteome has been greatly enhanced by technological advances in the proteomics field as the use of the two-dimensional differential in-gel electrophoresis, a gel-based approach which allowed the analysis of proteins from complex ...
Rosalia Di Gerlando +6 more
doaj +1 more source