Results 181 to 190 of about 135,255 (300)

Controlling pulsed field ablation efficacy during ablation procedures. [PDF]

Europace
Cespón-Fernández M, Davalos RV, Kueffer T, Khan Mahmoodi B, Reichlin T, Sarkozy A, Yap SC, Jacobs EJ, Gibert G, Asirvatham SJ.   +9 more
europepmc   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Advancing Electrochemotherapy in Melanoma and Non-Melanoma Skin Cancer: From Clinical Practice to Emerging Frontiers. [PDF]

Int J Mol Sci
Marrapodi R, Presaghi A, Migliano E, Bellei B.   +3 more
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Localized delivery of coding nucleic acids into adherent cells by in situ electroporation: integrated impedance-based monitoring allows for loss-of-function or gain-of-function screening. [PDF]

Sci Rep
Grimm AK, Balk S, Göpferich A, Breunig M, Aubele S, Zemella A, Wegener J.   +6 more
europepmc   +1 more source

z‐VAD‐FMK triggers macrophage necroptosis during mycobacterial infection via a non‐canonical off‐target mechanism

mLife, EarlyView.
Abstract Macrophages are the predominant cell type infected by Mycobacterium tuberculosis (Mtb) in tuberculosis (TB). Death of Mtb‐infected macrophages promotes tissue pathology and releases Mtb to infect other cells, suggesting that inhibiting the death of Mtb‐infected macrophages could be an adjunctive treatment of TB.
Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi‐Nan Gong, Carl F. Nathan, Li Zhang   +10 more
wiley   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

A PepFect14 analog improves non-viral CRISPR delivery in primary human cells to facilitate genome editing and repair. [PDF]

Bioeng Transl Med
du Rand A, Masterson C, Verdon D, Siow A, Loef E, Dunbar R, Kingston R, Harris P, Sheppard H.   +8 more
europepmc   +1 more source

The construction of a genome‐wide transposon library of Glaesserella parasuis and its use to identify genes essential for in vitro and in vivo survival

mLife, EarlyView.
Abstract Glaesserella parasuis is an important porcine pathogen that commonly colonizes the upper respiratory tract of pigs and is the etiological agent of Glässer's disease, causing substantial economic losses in the global swine industry. This study aimed to identify genes essential for both in vitro growth and in vivo pathogenicity of G.
Xiaowei Gong, Yuqian Shi, Liuqing He, Qingpo Cui, Guanzheng Zhao, Shuo Xu, Luyu Ying, Qin Yang, Xiaoxia Qin, Tong Sun, Xiaotong Jiang, Juanjuan Wang, Zhangqi Shen, Mengjiao Fu   +13 more
wiley   +1 more source

Non-thermal ablation and drug delivery by electroporation: expanding current indications beyond cancer and cardiac treatment. [PDF]

Radiol Oncol
Miklavcic D, Cindric H, Davalos RV, Deschamps F, Gehl J, Kos B, Kramar P, Kuhelj D, Meijerink MR, Soden D, Stabuc M, Sersa G.   +11 more
europepmc   +1 more source