Results 181 to 190 of about 182,543 (292)

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

The Rising Power of Electrochemotherapy in Musculoskeletal Oncology. [PDF]

Curr Oncol
Papalexis N, Peta G, Quarchioni S, Campanacci L, Gasbarrini A, Tedesco G, Carta M, Di Carlo M, Miceli M, Facchini G.   +9 more
europepmc   +1 more source

Cell division responsive peptides for optimized plasmid DNA delivery : the mitotic window of opportunity? [PDF]

, 2014
De Smedt, Stefaan, Demeester, Jo, Lucas, Bart, Remaut, Katrien, Symens, Nathalie   +4 more
core   +1 more source

Cirsium arvense management with electrical weed control and clopyralid

Pest Management Science, EarlyView.
Electrical weed control (EWC) treatments reduced Cirsium arvense biomass by ≤95% and suppressed new shoot emergence by 70–95%, achieving control comparable to clopyralid. Sequential or integrated applications enhanced efficacy, demonstrating EWC's potential as a nonchemical tool for perennial weed management in orchard systems.
Luisa Carolina Baccin, Marcelo L. Moretti   +1 more
wiley   +1 more source

Breaking the cell wall for efficient DNA delivery to diatoms. [PDF]

Nat Commun
Walker EJL, Pampuch M, Deng L, Li Y, Tran G, Mock T, Karas BJ.   +6 more
europepmc   +1 more source

Capture, Confine, Characterize: High‐Throughput Dielectrophoresis‐Based Single‐Cell Microfluidics Platform to Analyze Mammalian and Yeast Cells Using Raman Spectroscopy

Small, EarlyView.
Traditional single‐cell analysis lacks the capacity for real‐time monitoring. This study presents Microfluidic dielectrophoretic Arresting System (MiDAS), a microelectrofluidic platform using dielectrophoresis for single‐cell and droplet trapping. MiDAS immobilizes diverse samples (cells, beads, droplets) for optical imaging and Raman spectroscopy. Its
Bum‐Joon Jung, Allison Hohreiter, Runjie Chen, Dylan Cook, Linus Hansen, Sunny Taylor, Koseki J. Kobayashi‐Kirschvink, Joseph Chaiken, Supratik Guha, Anindita Basu   +9 more
wiley   +1 more source

Establishment of CRISPR-Cas9-Mediated Gene Editing in the Swimming Crab Portunus trituberculatus. [PDF]

Molecules
Wang X, Chen X, Zhou Y, Zhao Y, Shi C, Li R, Liu L, Mu C, Song W, Wang C.   +9 more
europepmc   +1 more source

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

High-intensity irreversible electroporation targeting intracellular structures enhance tumor ablation in lung cancer models. [PDF]

PLoS One
Kim HB, Youm JY, Yang JM, Sim SB.
europepmc   +1 more source

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

Yeast, EarlyView.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias, Fernanda Pinheiro Moreira Freitas, Eduardo Luís Menezes de Almeida, Luciano Gomes Fietto, Agustin Zsögön, Wendel Batista da Silveira   +5 more
wiley   +1 more source