Results 191 to 200 of about 135,255 (300)

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles. [PDF]

Mol Ther Nucleic Acids
Ramamurthy A, Scimonelli G, Murphy WL, Saha K.   +3 more
europepmc   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Rapid and Highly Efficient CRISPR-Cas9 RNP Genome Editing in Primary ILC2s. [PDF]

Eur J Immunol
Candelotti AM, Garzillo G, Bartolini S, Di Censo C, Peruzzi G, Stabile H, Fionda C, Sciumè G, Pietropaolo G.   +8 more
europepmc   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Erratum: Intramuscular plasmid DNA electroporation sequesters neoantigen-specific CD8⁺ T cells in treated muscle and limits tumor infiltration. [PDF]

Mol Ther Oncol
Bianchi A, Esposito M, Giacomelli T, Esposito I, Tonini C, Aurisicchio L, Palombo F.   +6 more
europepmc   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Correction: Gao et al. Dimethyl Sulfoxide-Free Cryopreservation of Human Umbilical Cord Mesenchymal Stem Cells Based on Zwitterionic Betaine and Electroporation. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7445. [PDF]

Int J Mol Sci
Gao L, Zhou Q, Zhang Y, Sun S, Lv L, Ma P, Yang J, Liu M, Zhang L, Wang X, Zhan L.   +10 more
europepmc   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Hybrid modeling of electroporation and impedance spectroscopy for label free characterization of stem cells. [PDF]

Sci Rep
Sherif S, Ghallab YH, Ismail Y.
europepmc   +1 more source