Results 191 to 200 of about 127,262 (303)

Lipid nanoparticle mRNA delivery preserves CAR T cell cytotoxicity and limits exhaustion compared to electroporation. [PDF]

Mol Ther Nucleic Acids
Picht S, Farrera-Sal M, Hiller AL, Brumhard S, Klaas AM, Schulenberg S, Friedrich R, Scholz C, Hemmerling L, Simon DN, Krönke G, Pichon C, Sander LE, Volk HD, Gossen M, Schmueck-Henneresse M, Drzeniek NM.   +16 more
europepmc   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Integrating design-of-experiments (DOE) optimization and risk assessment towards a safe and simplified electroporation protocol for Toxoplasma gondii. [PDF]

PLoS Negl Trop Dis
Srivastava PN, Perewernycky N, Filippo L, Lefsrud LM, Ungrin M.   +4 more
europepmc   +1 more source

Integrating Chemical, Electrical, and Photonic Effects Into a Unified ETOP‐Based Plasma Dose Framework

High Voltage, EarlyView.
ABSTRACT In plasma medicine and biological applications, plasmas typically deliver a complex combination of reactive chemical species and multiple physical energy components. However, establishing a unified and comparable dose metric to characterise their integrated biological effects remains a major challenge that continues to limit progress in this ...
Erqi Wu, Jialin Liu, Zhiyu Li, Dawei Liu, Lanlan Nie, Xinpei Lu   +5 more
wiley   +1 more source

Monoclonal Antibodies Accessing the Cytosol of Living Cells and Binding to Polo-Like Kinase 1 Interdomain Linker Affect Mitotic Behavior. [PDF]

Chembiochem
Steyer C, Amé JC, Donzeau M, Shen K, Chiper M, Zuber G.   +5 more
europepmc   +1 more source

Mapping the lineage of prostate tissue ablation medical device predicates for focal therapy of prostate cancer approved via the FDA 510(k) clearance pathway

Surgical Practice, EarlyView.
Abstract Objective Medical devices are reviewed by the US Food and Drug Administration (FDA) for safety and effectiveness. Class II devices can receive 510(k) clearance if they are “substantially equivalent” to an existing predicate device. This process can be repeated iteratively, leading to a lineage of predicates for newly cleared devices.
Yiting Lin, Amir Khan, Arvin George, Mohummad Minhaj Siddiqui   +3 more
wiley   +1 more source

Combination of irreversible and calcium electroporation to overcome heterogeneity-associated incomplete ablation in the pancreas. [PDF]

Sci Rep
Ko MJ, Yoon HY.
europepmc   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

RNA-based co-transfer of human CD8αβ with WT1-specific TCRαβ redirects tumor recognition by CD4 and γδ T-cells towards MHC class I-restricted WT1 epitopes and boosts CD8 T-cell responses with or without CD3 mRNA. [PDF]

Exp Hematol Oncol
Campillo-Davo D, Flumens D, Berneman ZN, Fujiki F, Roex G, Versteven M, Van Acker HH, Van Tendeloo VFI, Sugiyama H, Anguille S, Lion E.   +10 more
europepmc   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source