Results 191 to 200 of about 182,543 (292)

Optimization of RNP-CRISPR for high-efficiency gene editing in mouse intestinal organoids. [PDF]

Mol Cell Biochem
Cao X, He Y, Guo H, Cao X, Zhang D, Lai Y, Yang W, Ma Z, Yu X, Wang L, Li D, Zeng Z.   +11 more
europepmc   +1 more source

Mapping the lineage of prostate tissue ablation medical device predicates for focal therapy of prostate cancer approved via the FDA 510(k) clearance pathway

Surgical Practice, EarlyView.
Abstract Objective Medical devices are reviewed by the US Food and Drug Administration (FDA) for safety and effectiveness. Class II devices can receive 510(k) clearance if they are “substantially equivalent” to an existing predicate device. This process can be repeated iteratively, leading to a lineage of predicates for newly cleared devices.
Yiting Lin, Amir Khan, Arvin George, Mohummad Minhaj Siddiqui   +3 more
wiley   +1 more source

Endogenous Site-Specific Encoding of Trifluoromethyl-Bearing Phenylalanine and Tryptophan for in-Cell ¹⁹F NMR. [PDF]

J Am Chem Soc
Augustin G, Bhinderwala F, Alexander ND, Hernández I, Stanisheuski S, Monnie CM, Eddins AJ, Gangarde YM, Soloshonok VA, Oiarbide M, Landa A, Cooley RB, Gronenborn AM, Mehl RA.   +13 more
europepmc   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Bleomycin ElectroScleroTherapy (BEST): mechanistic parallels to electrochemotherapy, experimental models, and unresolved questions. [PDF]

Radiol Oncol
Lisec B, Cemazar M, Muir T, Omerzel M, Jesenko T, Markelc B, Groselj A, Dezman R, Stabuc M, Kuhelj D, Sersa G.   +10 more
europepmc   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Invasive properties of patient-derived glioblastoma cells after reversible electroporation <i>in vitro</i>. [PDF]

Radiol Oncol
Blazic A, Majc B, Novak M, Breznik B, Rems L.   +4 more
europepmc   +1 more source

Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules. [PDF]

, 2019
Cao, Yuhong, Cestellos-Blanco, Stefano, Doudna, Jennifer A, Ma, Enbo, Qiu, Ruoyi, Su, Yude, Yang, Peidong   +6 more
core  

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Two Optimized Methods for Efficient, Stable and Transient Transformation of Broccoli (<i>Brassica oleracea</i> Var. Italica). [PDF]

Plants (Basel)
Coronado-Martín A, Atarés A, Porcel R, Yenush L, Mulet JM.   +4 more
europepmc   +1 more source