Investigating membrane breakdown of neuronal cells exposed to nonuniform electric fields by finite-element modeling and experiments [PDF]
, 2002 High electric field strengths may induce high cell membrane potentials. At a certain breakdown level the membrane potential becomes constant due to the transition from an insulating state into a high conductivity and high permeability state.
Heida, Tjitske +3 more
core +3 more sources
Engineering Bacterial Secretion Systems for Enhanced Tumor Imaging and Surgical Guidance
Advanced Materials, EarlyView.This study presents a novel contrast agent platform, Streptavidin Associated Salmonella (SAS), for fluorescence image guided surgery. SAS selectively colonizes tumors and secretes streptavidin, enabling precise delineation of invasive tumor margins with prolonged signal retention.
Dohee Lee +14 more
wiley +1 more source
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity [PDF]
, 2008 In the previous studies, we showed that strong Fgf8 signaling activates the Ras-ERK pathway to induce cerebellum. Here, we show importance of negative regulation of this pathway.
Asuka Suzuki-Hirano +2 more
core +1 more source
Multimodal Platforms for Light‐Mediated Organic Bioelectronics
Advanced Materials Interfaces, EarlyView.Optobioelectronic devices are paving the way for different types of interfacing with cells, in addition to classical electrical interfacing. Here, a future perspective for research in this field is discussed, in which different classes of light‐responsive materials are combined to create a highly dynamic interface that truly integrates with biological ...
Giovanna Gentile +4 more
wiley +1 more source
Modelling the positioning of single needle electrodes for the treatment of breast cancer in a clinical case [PDF]
, 2015 Background: Breast cancer is the most common cancer in women worldwide and is the second most common cause of cancer death in women. Electrochemotherapy (ECT) used in early-phase clinical trials for the treatment of primary breast cancer resulted in a ...
Claudio, Botti +8 more
core
Chemotactic properties of Escherichia coli mutants having abnormal Ca2+ content [PDF]
, 1995 The calA, calC, and calD mutants of Escherichia coli are known to be sensitive to Ca2+ (R. N. Brey and B. P. Rosen, J. Bacteriol. 139:824-834, 1979).
Adler, Julius, Tisa, Louis S.
core +3 more sources
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans. [PDF]
, 2014 To better understand the role of radial glial (RG) cells in the evolution of the mammalian cerebral cortex, we investigated the role of RG cells in the dorsal cortex and dorsal ventricular ridge of the turtle, Trachemys scripta elegans.
Clinton, Brian K +4 more
core +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Accelerated Bone Healing via Electrical Stimulation
Advanced Science, EarlyView.Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun +4 more
wiley +1 more source