Results 111 to 120 of about 201,447 (356)

Quantification of seminolipid by LC-ESI-MS/MS-multiple reaction monitoring: compensatory levels in Cgt mice[S]

Journal of Lipid Research, 2010
Seminolipid, also known as sulfogalactosylglycerolipid (SGG), plays important roles in male reproduction. Therefore, an accurate and sensitive method for SGG quantification in testes and sperm is needed.
Kessiri Kongmanas, Hongbin Xu, Arman Yaghoubian, Laura Franchini, Luigi Panza, Fiamma Ronchetti, Kym Faull, Nongnuj Tanphaichitr   +7 more
doaj   +1 more source

Electronic Spectroscopy of Isolated DNA Polyanions

, 2018
In solution, UV-vis spectroscopy is often used to investigate structural changes in biomolecules (i.e., nucleic acids), owing to changes in the environment of their chromophores (i.e., the nucleobases).
Daly, Steven, Gabelica, Valérie, Porrini, Massimiliano, Rosu, Frederic   +3 more
core   +2 more sources

Influence of the sebaceous gland density on the stratum corneum lipidome [PDF]

, 2018
The skin surface lipids (SSL) result from the blending of sebaceous and epidermal lipids, which derive from the sebaceous gland (SG) secretion and the permeability barrier of the stratum corneum (SC), respectively.
Camera, Emanuela, Kozul, Nina, Ludovici, Matteo, Materazzi, Stefano, Picardo, Mauro, Risoluti, Roberta   +5 more
core   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Metabolite fingerprinting by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

SLAS Technology
The adoption of mass spectrometry for high-throughput screening in drug discovery has become increasingly prevalent and has enabled label-free screening against diverse targets.
Alena N. Joignant, Fan Pu, Shaun M. McLoughlin, James W. Sawicki, Andrew J. Radosevich, Renze Ma, Jon D. Williams, Sujatha M. Gopalakrishnan, Nathaniel L. Elsen   +8 more
doaj   +1 more source

Molecular characterization of S‐ and N‐containing organic constituents in ambient aerosols by negative ion mode high‐resolution Nanospray Desorption Electrospray Ionization Mass Spectrometry: CalNex 2010 field study [PDF]

, 2014
Rachel E. O’Brien, Alexander Laskin, Julia Laskin, Caitlin L. Rubitschun, Jason D. Surratt, Allen H. Goldstein   +5 more
openalex   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Three-Dimensional-Printed Lateral Extraction Enhanced Desorption Electrospray Ionization Source for Mass Spectrometry

Applied Sciences
This paper introduces a novel Lateral Extraction Enhanced Desorption Electrospray Ionization (LEE-DESI) source. This source is specifically designed to tackle the crucial issue of electric field interference in dual-channel ambient ionization mass ...
Jilin Liu, Xiang Qian
doaj   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Supplementary Figure Legends from Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry

, 2023
Nima Abbassi‐Ghadi, Ottmar Golf, Sacheen Kumar, Stefan Antonowicz, James McKenzie, Juzheng Huang, Nicole Strittmatter, Hiromi Kudo, Emrys A. Jones, Kirill Veselkov, Robert Goldin, Zoltán Takáts, George B. Hanna   +12 more
openalex   +1 more source