Results 151 to 160 of about 2,688,547 (318)
The Finite Element Method Fundamentals and Applications
, 1973 The Finite Element Method: Fundamentals and Applications demonstrates the generality of the finite element method by providing a unified treatment of fundamentals and a broad coverage of applications.
Norrie, Douglas H., de Vries, Gerard
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Enrichment of the Boundary Element Method through the Partition of Unity Method for Fracture Analysis using Local and Global Formulations [PDF]
, 2010 The present thesis proposes an innovative technique of applying enrichment to the Boundary Element Method to allow accurate analysis of 2D crack problems. An overview of fracture mechanics is given, with particular emphasis given to numerical methods and
SIMPSON, ROBERT
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Knowledge Transfer Partnership Final Report: Fourth Element/Falmouth University
The project objectives were to develop product design (drysuit) and manufacturing techniques using state of the art digital measurement and pattern cutting technology. Over a two year period Fourth Element Limited and Falmouth University partnered to:
Fourth Element Limited, Boddy, John
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Finite element solutions to boundary value problems
, 1976 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis consists of two distinct parts which deal with two-point boundary value problems and parabolic problems, respectively.
Moore, P
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source