Results 161 to 170 of about 2,688,547 (318)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A control volume based formulation of the discrete Kirchoff triangular thin plate bending element
, 2009 A control volume method is presented for predicting the displacement and rotation of thin transversely loaded flat plates. The new procedure uses discrete Kirchoff triangle (DKT) elements but introduces a dual mesh of interconnected control volumes (CVs)
Wheel, M. +3 more
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
On the Implementation of a Compact Vertical DC Biasing Network with Significantly Reduced RF Components for Phase-Shifter-Free Beam Steering. [PDF]
Sensors (Basel)Zheng S, Qian B, Chen X, Kishk AA.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Flexible Graphene-Based S-Band Metasurface Conformal Array Antenna for UAV Platforms. [PDF]
Materials (Basel)Li J, Li P, Zeng M, Xin Y, Zu H, Song R.
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Closed-Loop Iterative Self-Calibration of Initial Phase in Phased Arrays. [PDF]
Sensors (Basel)Huang X, Huang D, Chen B, Wu B.
europepmc +1 more source