Results 141 to 150 of about 206,297 (286)

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

The evolving roles of extracellular vesicles in embryo-maternal communication

Communications Biology
Mammalian reproduction relies on precise maternal-fetal communication, wherein immune modifications foster tolerance toward the semi-allogeneic embryo. Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as crucial mediators,
Alireza Fazeli, Kasun Godakumara
doaj   +1 more source

PRC1‐Mediated H2Aub Loop Formation and Function in Arabidopsis

Advanced Science, EarlyView.
In the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co‐localize, and some regions are marked exclusively by H2Aub. By using Capture‐Hi‐C, it is found that H2Aub loops are preferentially established between two H2Aub enriched regions.
Lingxiao Luo, Minqi Yang, Zhihan Song, Yali Liu, Suxin Xiao, Dingyue Wang, Myriam Calonje, Hang He, Yue Zhou   +8 more
wiley   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

Polyadenylation Complex CFII Recognizes Downstream Cis‐element for Pre‐mRNA Polyadenylation Through Interaction with an RNA‐Binding Protein in Arabidopsis

Advanced Science, EarlyView.
This study investigates the cis‐element in pre‐mRNA recognized by the polyadenylation CFII complex. It elucidates how the CFII complex recognizes the consensus cis‐element downstream of the poly(A) site for pre‐mRNA alternative polyadenylation. This comprehensive research provides novel insights into the interaction between 3′ end processing complexes ...
Ying Cao, Ying Guo, Zhibo Yu, Huajian Nie, Jing Yang, Dingfu Qiu, Qiyu Li, Xu Xin, Chang Cheng, Yan Li, Xudong Shang, Yuling Jiao, Qingshun Quinn Li, Ligeng Ma   +13 more
wiley   +1 more source

Immunoisolation of centrosomes from Drosophila melanogaster [PDF]

, 2005
Lange, B., Lehmann, V., Müller, H.
core   +2 more sources

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

Advanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li, Shiyu Sun, Yuting Xu, Jixiang Zhang, Yi Du, Yaxin Cao, Zhaodi Liao, Yali Xie, Xinyan Bian, Jiantao Huang, Meijiao Wang, Zhen Liu, Qiang Sun, Falong Lu   +13 more
wiley   +1 more source

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single‐Cell RNA‐Seq Samples

Advanced Science, EarlyView.
FemXpress is a computational tool that leverages X‐linked single nucleotide polymorphisms (SNPs) to group cells by the origin of the inactivated X chromosome in female single‐cell RNA sequencing (scRNA‐Seq) data. It demonstrates strong performance on both simulated and real datasets without requiring parental genomic information, and can also identify ...
Xin Wang, Yingke Ma, Fan Li, Wentao Cui, Tianshi Pan, Siqi Wang, Sinan Ma, Qingtong Shan, Chao Liu, Yukai Wang, Ying Zhang, Yuanchun Zhou, Wei Li, Pengfei Wang, Qi Zhou, Guihai Feng   +15 more
wiley   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source