Results 31 to 40 of about 205,548 (309)

Molecular recording of mammalian embryogenesis. [PDF]

open access: yes, 2019
Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt   +13 more
core   +2 more sources

The meganuclease I-SceI containing nuclear localization signal (NLS-I-SceI) efficiently mediated mammalian germline transgenesis via embryo cytoplasmic microinjection. [PDF]

open access: yesPLoS ONE, 2014
The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognition ...
Yong Wang   +7 more
doaj   +1 more source

Modeling mammalian gastrulation with embryonic stem cells

open access: yes, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita   +65 more
core   +1 more source

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]

open access: yes, 2018
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David   +7 more
core   +1 more source

The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. [PDF]

open access: yesPLoS ONE, 2014
The in vitro production of mammalian embryos suffers from high frequencies of developmental failure due to excessive levels of permanent embryo arrest and apoptosis caused by oxidative stress.
Dean H Betts   +2 more
doaj   +1 more source

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

open access: yes, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina   +3 more
core   +1 more source

Erythroid development in the mammalian embryo [PDF]

open access: yesBlood Cells, Molecules, and Diseases, 2013
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells
Margaret H, Baron   +2 more
openaire   +2 more sources

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw. [PDF]

open access: yes, 2019
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their ...
A Abzhanov   +395 more
core   +1 more source

Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

open access: yeseLife
The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry-breaking event is executed through polarization of cells at the 8 cell stage and subsequent asymmetric divisions,
Adiyant Lamba   +11 more
doaj   +1 more source

Prospects for transgenesis in the chick [PDF]

open access: yes, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman   +52 more
core   +1 more source

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