Results 31 to 40 of about 285,727 (331)

Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster [PDF]

Open Biology, 2018
The onset of metazoan development requires that two terminally differentiated germ cells, a sperm and an oocyte, become reprogrammed to the totipotent embryo, which can subsequently give rise to all the cell types of the adult organism.
Danielle C. Hamm, Melissa M. Harrison
doaj   +1 more source

Sexual Dimorphism of the Heart: Genetics, Epigenetics, and Development

Frontiers in Cardiovascular Medicine, 2021
The democratization of genomic technologies has revealed profound sex biases in expression patterns in every adult tissue, even in organs with no conspicuous differences, such as the heart.
Daniel F. Deegan, Priya Nigam, Nora Engel   +2 more
doaj   +1 more source

Mechanism of DUX-induced differentiation of mESC into extraembryonic endoderm

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the effect of double homeobox (DUX) protein on the differentiation potential of mouse embryonic stem cells (mESCs) into extraembryonic endoderm (XEN) and the possible mechanism of its action.Methods·Overexpression of DUX cell lines ...
HONG Lei, GUO Chuanliang, CAI Qin, LI Wanrui, ZENG Yitao, XUE Yan, ZENG Fanyi   +6 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Desynchronizing Embryonic Cell Division Waves Reveals the Robustness of Xenopus laevis Development

Cell Reports, 2017
The early Xenopus laevis embryo is replete with dynamic spatial waves. One such wave, the cell division wave, emerges from the collective cell division timing of first tens and later hundreds of cells throughout the embryo.
Graham A. Anderson, Lendert Gelens, Julie C. Baker, James E. Ferrell, Jr.   +3 more
doaj   +1 more source

A Quarter Century History of ATML1 Gene Research

Plants, 2021
The cloning of the ATML1 gene, encoding an HD-ZIP class IV transcription factor, was first reported in 1996. Because ATML1 mRNA was preferentially detected in the shoot epidermis, cis-regulatory sequences of ATML1 have been used to drive gene expression ...
Hiroyuki Iida, Shinobu Takada
doaj   +1 more source

Somatic embryogenesis and phase change in trees [PDF]

, 2011
The advantages of clonai plantations are obvious for a lot of tree species. Somatic embryogenesis is a clonai propagation method with the greatest potential for achieving this goal, especially if combined to genetic engineering.
Berthouly, Marc, Lardet, Ludovic, Monteuuis, Olivier, Montoro, Pascal, Verdeil, Jean-Luc   +4 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H2S nearby through the AKT/NRF2 signaling pathway

Frontiers in Pharmacology
Cystathionine γ-lyase (CSE) is a major enzyme that produces hydrogen sulfide (H2S). Herein, we report how CSE plays a previously unknown role in regulating the antioxidant effects of the mitochondria in human umbilical vein endothelial cells by releasing
Tingting Xiao, Shun Chen, Ge Yan, Junmin Zheng, Qingzhu Qiu, Shujia Lin, Yanfang Zong, Haishuang Chang, Alex Chia Yu Chang, Ying Wu, Cuilan Hou   +10 more
doaj   +1 more source

Transcriptome Analysis of the Oriental Fruit Fly Bactrocera dorsalis Early Embryos

Insects, 2020
The oriental fruit fly, Bactrocera dorsalis (Hendel), is one of the most devastating and highly invasive agricultural pests world-wide, resulting in severe economic loss.
Wei Peng, Shuning Yu, Alfred M. Handler, Hongyu Zhang   +3 more
doaj   +1 more source