Results 51 to 60 of about 138,368 (322)

Cognition coming about: self-organisation and free-energy [PDF]

arXiv, 2020
Wright and Bourkes compelling article rightly points out that existing models of embryogenesis fail to explain the mechanisms and functional significance of the dynamic connections among neurons. We pursue their account of Dynamic Logic by appealing to the Markov blanket formalism that underwrites the Free Energy Principle.
arxiv  

Transient Stiffness Patterning in Hydrogels Driven by Dissipative Mechanochemical Coupling

Advanced Functional Materials, EarlyView.
Force‐induced disulfide bond rupture in a polymer‐based hydrogel, coupled with chemical or electrochemical reoxidation, leads to the transient modulation of the hydrogel's stiffness properties. High spatiotemporal control is achieved by this dissipative process, enabling the development of out‐of‐equilibrium stiffness patterns and transient, dose ...
Roberto Baretta, Maria F. Pantano, Marco Frasconi   +2 more
wiley   +1 more source

Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis [PDF]

BMC Genomics 8 (2007) 118, 2007
Xenopus tropicalis is an anuran amphibian species used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a smaller genome of 1.7 Gbp. Therefore X. tropicalis is more amenable to systematic transcriptome surveys.
arxiv   +1 more source

Pericyte‐Assisted Vascular Lumen Organization in a Novel Dynamic Human Blood‐Brain Barrier‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Organ‐on‐Chip (OoC) technology enables the precise modeling of the blood‐brain barrier (BBB). This study presents a microfluidic device that mimics brain microvessels, integrating co‐culture with pericytes and astrocytes under pulsatile flow. Results show that perivascular cells modulate endothelial morphology, promoting lumen formation and barrier ...
Vita Guarino, Elisabetta Perrone, Elisa De Luca, Alberto Rainer, Maura Cesaria, Alessandra Zizzari, Monica Bianco, Giuseppe Gigli, Lorenzo Moroni, Valentina Arima   +9 more
wiley   +1 more source

Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development

Advanced Healthcare Materials, EarlyView.
Synthetic matrix metalloproteinase (MMP)‐degradable polyethylene glycol (PEG)‐based hydrogels are developed to investigate the influence of mechanical and biochemical cues on cardioid development. Matrix stiffness and cell adhesion motifs significantly regulate cardioid formation, chamber morphogenesis, contractile function, and cardioid transcriptome.
Yuanhui Song, Michael Seitz, Andrew Kowalczewski, Nhu Y Mai, Era Jain, Huaxiao Yang, Zhen Ma   +6 more
wiley   +1 more source

Deep Reinforcement Learning of Cell Movement in the Early Stage of C. elegans Embryogenesis [PDF]

Bioinformatics, 2018, 2018
Cell movement in the early phase of C. elegans development is regulated by a highly complex process in which a set of rules and connections are formulated at distinct scales. Previous efforts have shown that agent-based, multi-scale modeling systems can integrate physical and biological rules and provide new avenues to study developmental systems ...
arxiv   +1 more source

Morphometric‐Assisted Prediction of Developmental Toxicity Using Stem Cell‐Based Embryo Models in Microwells

Advanced Healthcare Materials, EarlyView.
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar, Athanasia Zoi Pappa, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrecht   +4 more
wiley   +1 more source

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

Nature Communications
Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear.
Kanako Matsumoto, Yuki Akieda, Yukinari Haraoka, Naoki Hirono, Hiroshi Sasaki, Tohru Ishitani   +5 more
doaj   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Female gametogenesis and early seed development in Amaranthus hypochondriacus L.

Botan‪ical Sciences, 2018
Background: Attention to amaranth grains has increased in recent years due to the nutritional value of their seed proteins, which have high levels of the amino acid lysine. However, there is no detailed study describing the stages of seed development in
Angelica Barrales-López, Lorenzo Guevara-Olvera, Eduardo Espitia-Rangel, Mario M. González-Chavira, Aurea Bernardino-Nicanor, Leopoldo Gonzalez-Cruz, Wilson Huanca-Mamani, Gerardo Acosta-García   +7 more
doaj   +1 more source