Results 31 to 40 of about 130,317 (259)

Expression of Genes Involved in ABA and Auxin Metabolism and LEA Gene during Embryogenesis in Hemp

Plants, 2022
The level of phytohormones such as abscisic acid (ABA) and auxins (Aux) changes dynamically during embryogenesis. Knowledge of the transcriptional activity of the genes of their metabolic pathways is essential for a deeper understanding of embryogenesis ...
Daniel Král, Josef Baltazar Šenkyřík, Vladan Ondřej   +2 more
doaj   +1 more source

The small intestinal mucosa and its stem cells

Journal of Pediatric and Neonatal Individualized Medicine, 2016
In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in
Rossano Ambu, Clara Gerosa, Giorgia Locci, Eleonora Obinu, Alberto Ravarino, Anna De Magistris, Alessandra Reali, Peter Van Eyken, Gavino Faa, Silvia Nati, Laura Vinci   +10 more
doaj   +1 more source

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

Cells, 2022
Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak, Izabela Woclawek-Potocka, Krzysztof Lukaszuk   +2 more
doaj   +1 more source

Embryogenesis in Hydra

The Biological Bulletin, 1997
Embryogenesis in hydra includes a variable period of dormancy; and this period, as well as subsequent stages through hatching, takes place within a thick cuticle that hinders observation. Thus, although the early stages of development have been well-characterized qualitatively, the middle and later stages are only poorly understood.
Martin, V J, Littlefield, C L, Archer, William E., Bode, Hans R.   +3 more
openaire   +4 more sources

Mechanism of DUX-induced differentiation of mESC into extraembryonic endoderm

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the effect of double homeobox (DUX) protein on the differentiation potential of mouse embryonic stem cells (mESCs) into extraembryonic endoderm (XEN) and the possible mechanism of its action.Methods·Overexpression of DUX cell lines ...
HONG Lei, GUO Chuanliang, CAI Qin, LI Wanrui, ZENG Yitao, XUE Yan, ZENG Fanyi   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Experimental study of modifying influence of nanoaquachelate gold citrate on embryotoxicity of lead acetate in rats.

Medičnì Perspektivi, 2014
Among modern investigations in nanobiotechnology, only a small part of them is devoted to the influence of nanometals on reproductive organs and embryogenesis.
V. F. Shatorna, V. I. Garetz, E. M. Biletska, N. М. Onul, O. O. Nefyodova, S. S. Ostrovskа, S. V. Stepanov, N. I. Dihno   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H2S nearby through the AKT/NRF2 signaling pathway

Frontiers in Pharmacology
Cystathionine γ-lyase (CSE) is a major enzyme that produces hydrogen sulfide (H2S). Herein, we report how CSE plays a previously unknown role in regulating the antioxidant effects of the mitochondria in human umbilical vein endothelial cells by releasing
Tingting Xiao, Shun Chen, Ge Yan, Junmin Zheng, Qingzhu Qiu, Shujia Lin, Yanfang Zong, Haishuang Chang, Alex Chia Yu Chang, Ying Wu, Cuilan Hou   +10 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source