Results 71 to 80 of about 261,248 (281)

Differential spatial distribution of miR165/6 determines variability in plant root anatomy [PDF]

, 2017
A clear example of interspecific variation is the number of root cortical layers in plants. The genetic mechanisms underlying this variability are poorly understood, partly due to the lack of a convenient model.
Bertolotti, Gaia, Costantino, Paolo, DELLO IOIO, Raffaele, Di Ruocco, Giovanna, Pacifici, Elena, Polverari, Laura, Sabatini, Sabrina, Tsiantis, Miltos   +7 more
core   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Molecular cloning and transcriptional activity of a new Petunia calreticulin gene involved in pistil transmitting tract maturation, progamic phase, and double fertilization [PDF]

, 2013
Calreticulin (CRT) is a highly conserved and ubiquitously expressed Ca2+-binding protein in multicellular eukaryotes. As an endoplasmic reticulum-resident protein, CRT plays a key role in many cellular processes including Ca2+ storage and release ...
A Christensen, AJ Crofts, AM Hassan, Anna Suwińska, BA Kwiatkowski, BQ Huang, CM Williams, CN Nardi, CO Lim, DE Nelson, E Gasteiger, E Zuckerkandl, F Chen, H Jin, HJ Li, HJ Li, HQ Tian, J Denecke, J Felsenstein, J Li, JC Huang, JL Went Van, JR Nevins, Justyna Prusińska, K Hsieh, K Tamura, Krzysztof Gumowski, L Navazio, L Thelin, LI Gold, LL Ge, M Iwano, M Lenartowska, M Lenartowska, M Lenartowska, M Michalak, MA Larkin, Marta Lenartowska, MTM Willemse, N Blom, N Borisjuk, N Saitou, P Mariani, P Shaw, Robert Lenartowski, S Persson, S Persson, SF Altschul, SJ Coughlan, T Dresselhaus, T Ishimizu, UK Tirlapur, WA Wang, XL Ye, XY Jia, XY Jia, Y Fu, Y Saijo, YQ An, Z Li   +59 more
core   +2 more sources

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Chemo‐Selective Single‐Cell Metabolomics Reveals the Spatiotemporal Behavior of Exogenous Pollutants During Xenopus Laevis Embryogenesis

Advanced Science
In‐depth profiling of embryogenesis‐associated endogenous and exogenous metabolic changes can reveal potential bio‐effects resulting from human‐made chemicals and underlying mechanisms.
Pengfei Li, Song Gao, Wanting Qu, Ying Li, Zhen Liu   +4 more
doaj   +1 more source

Early and mid-embryonic upregulation of chloride, calcium, and sodium transporter genes mark functional maturation of the chorioallantoic membrane in broiler embryos

Frontiers in Physiology
The chorioallantoic membrane (CAM) is essential for ion transport, acid-base homeostasis, and respiratory gas exchange during chicken embryonic development.
Sadid Al Amaz, Suman Poudel, Rajesh Jha, Birendra Mishra   +3 more
doaj   +1 more source

Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]

, 2013
Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin, Conway, Simon J., Harmon, Andrew W., Harvey, Richard P., Liu, Xiaoqian, Mikkola, Hanna K. A., Nakano, Atsushi, Nakano, Haruko, Nakano, Haruko, Nakashima, Yasuhiro, Pashmforoush, Mohammad, Sasidharan, Rajkumar, Schwartz, Robert J., Shin, Jae-Ho, van Handel, Ben   +14 more
core   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

EMBO Molecular Medicine, 2012
Insulin‐like growth factor 2 (IGF2) and the transformation related protein 53 (Trp53) are potent regulators of cell growth and metabolism in development and cancer. In vitro evidence suggests several mechanistic pathway interactions.
Victoria L. Haley, David J. Barnes, Ionel Sandovici, Miguel Constancia, Christopher F. Graham, Francesco Pezzella, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan   +8 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source