Results 91 to 100 of about 1,122,470 (212)

Expression of the Wilms tumor suppressor gene (Wt1) in a subpopulation of embryonic cardiomyocytes is required for cardiac development [PDF]

open access: yes, 2017
The Wilms’ tumour gene, WT1, encodes a zinc-finger transcription factor involved in the development of several organs. WT1 is expressed during mammalian embryonic development in many tissues, including the urogenital system, spleen, spinal cord ...
Ariza, Laura   +5 more
core  

Brain tumors induced in rats by human adenovirus type 12 [PDF]

open access: yes, 1974
Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu strains were injected intracranially with human adenovirus type 12. The incidence of intracranial tumors was 91% (30/33) in
Matsuo, Keisuke   +5 more
core   +1 more source

Connecting the dots: the role of fatigue in female infertility

open access: yesReproductive Biology and Endocrinology
Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model.
Wenzhu Li   +4 more
doaj   +1 more source

Human Umbilical Cord Blood-Derived Serum for Culturing the Supportive Feeder Cells of Human Pluripotent Stem Cell Lines

open access: yesStem Cells International, 2016
Although human pluripotent stem cells (hPSCs) can proliferate robustly on the feeder-free culture system, genetic instability of hPSCs has been reported in such environment. Alternatively, feeder cells enable hPSCs to maintain their pluripotency.
Ruttachuk Rungsiwiwut   +5 more
doaj   +1 more source

Esterase Activity in Embryonic Development

open access: yesExperimental Biology and Medicine, 1968
SummaryEsterase patterns characteristic for duodenum, liver, and pancreas in different stages of avian embryo development were studied with polyacrylamide disc gel electrophoresis. Embryonic and adult rat tissues were studied for comparison. It was found that the electrophoretic patterns of chicken liver and duodenum were similar for all developmental ...
Z, Szafran, K S, McCarty
openaire   +2 more sources

Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos

open access: yesNature Communications
The development and origin of animal body forms have long been intensely explored, from the analysis of morphological traits during antiquity to Newtonian mechanical conceptions of morphogenesis. Advent of molecular biology then focused most interests on
Ngoc Minh Nguyen, Emmanuel Farge
doaj   +1 more source

CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development

open access: yesiScience, 2019
Summary: There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and ...
Zhen-Peng Si   +8 more
doaj   +1 more source

JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion

open access: yesAdvanced Science
Recurrent spontaneous abortion (RSA) is a pregnancy‐related condition with complex etiology. Trophoblast dysfunction and abnormal macrophage polarization and metabolism are associated with RSA; however, the underlying mechanisms remain unknown.
Xin Chen   +7 more
doaj   +1 more source

Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans

open access: yesCell Death and Disease
Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility.
J. Zimmer   +7 more
doaj   +1 more source

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

open access: yes, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L.   +4 more
core  

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