Fast fluorescence microscopy for imaging the dynamics of embryonic development [PDF]
, 2008 Live imaging has gained a pivotal role in developmental biology since it increasingly allows real-time observation of cell behavior in intact organisms.
Bakal C +43 more
core +2 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Sea Spider development: How the encysting Anoplodactylus eroticus matures from a buoyant nymph to a grounded adult [PDF]
arXiv, 2013 In order to understand how animals evolved over time, biologists must learn how their body parts form during their development. The following is a detailed description of how one species of sea spider transforms from a hatchling to an 8-legged adult. Pycnogonids, or sea spiders, comprise a primitive lineage of arthropods.
arxiv
Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. [PDF]
, 2018 Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the
Chisholm, Andrew D +3 more
core +2 more sources
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Retinoids in Embryonic Development
Biomolecules, 2020 Retinoids constitute a class of compounds chemically related to vitamin A [...]
Michael Schubert, Yann Gibert
doaj +1 more source
Hematopoietic cancers and Nup98 fusions: determining common mechanisms of malignancy [PDF]
, 2012 Chromosomal aberrations are very frequent in leukemias and several recurring mutations capable of malignant transformation have been described. These mutations usually occur in hematopoietic stem cells (HSC), transforming them into leukemia stem cells.
arxiv +1 more source
Erythroid anion transporter assembly is mediated by a developmentally regulated recruitment onto a preassembled membrane cytoskeleton [PDF]
, 1987 Analysis of the expression and assembly of the anion transporter by metabolic pulse-chase and steady-state protein and RNA measurements reveals that the extent of association of band 3 with the membrane cytoskeleton varies during chicken embryonic ...
Cox, John V. +2 more
core +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Four Ways from Universal to Particular: How Chomsky's Language-Acquisition Faculty is Not Selectionist [PDF]
arXiv, 2014 Following the development of the selectionist theory of the immune system, there was an attempt to characterize many biological mechanisms as being "selectionist" as juxtaposed to "instructionist." But this broad definition would group Darwinian evolution, the immune system, embryonic development, and Chomsky's language-acquisition mechanism as all ...
arxiv