Results 21 to 30 of about 1,228,315 (316)

Developmental potential of aneuploid human embryos cultured beyond implantation

Nature Communications, 2020
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz   +11 more
doaj   +1 more source

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Adams, Aijö, Airik, Anders, Brown, Dorr, Geyer, Huang, Lu, MacArthur, Park, Rodriguez-Zas, Spring, Spring, Tsutsumi, Zamyadi, Zhang, Zhang   +17 more
core   +2 more sources

NF-κB activation impedes the transdifferentiation of hypertrophic chondrocytes at the growth plate of mouse embryos in diabetic pregnancy

Journal of Orthopaedic Translation, 2021
Background: Diabetes mellitus could cause numerous complications and health problems including abnormality of endochondral bone formation during embryogenesis. However, the underlying mechanisms still remain obscure.
Xi Liu, Fan Qian, Qiwei Fan, Li Lin, Meiyao He, Peizhi Li, Hongmei Cai, Lisha Ma, Xin Cheng, Xuesong Yang   +9 more
doaj  

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Nature Communications, 2017
Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2 ...
Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli   +9 more
doaj   +1 more source

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization [PDF]

, 2009
In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments.Whole ...
Aloisi, Bajenoff, Bekiaris, Bekiaris, Brendolan, Chen, Cupedo, Cupedo, Cupedo, Drayton, Eberl, Fan, Fu, Fu, Futterer, Honda, Kim, Kim, Kim, Kim, Kim, Kratz, Link, Luther, Luther, Luther, Mackay, Mebius, Meier, Ngo, Ngo, Nolte, Rennert, Rossi, Scandella, Sun, Togni, Veiga-Fernandes, Vondenhoff, Wang, White, Withers, Yokota, Yoshida   +43 more
core   +2 more sources

The first digestive movements in the embryo are mediated by mechanosensitive smooth muscle calcium waves [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2018, 373 (1759), pp.20170322, 2019
Peristalsis enables transport of the food bolus in the gut. Here, I show by dynamic ex-vivo intra-cellular calcium imaging on living embryonic gut transverse sections that the most primitive form of peristalsis that occurs in the embryo is the result of inter-cellular, gap-junction dependent calcium waves that propagate in the circular smooth muscle ...
arxiv   +1 more source

Correlation with basic differentiation processes of neurons [PDF]

, 1991
The development of the spinal cord involves the proliferation of neurons, their migration to well-defined areas, fiber outgrowth and synapse formation. The present study was designed to correlate the spatiotemporal pattern of expression of synaptophysin,
Altman, Angulo, Bööj, Cabalka, Chun, Dennis, Devoto, Hsu, Jahn, Jahn, Jahn, Kanemitsu, Kaplan, Knaus, Leclerc, Leube, Ley, Lizardi, Lupa, Mandler, Narayanan, Nornes, Nornes, Oppenheim, Phelps, Ritchie, Ruppert, Saito, Sarthy, Schilling, Stein, Südhof, Thomas, Vaughn, Vaughn, Vaughn, Vaughn, Xue   +37 more
core   +2 more sources

Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements

The Journal of Reproduction and Development, 2021
Upon mammalian fertilization, zygotic genome activation (ZGA) and activation of transposable elements (TEs) occur in early embryos to establish totipotency and support embryogenesis.
Shi-meng GUO, Ning-hua MEI, Jing YANG, Li-quan ZHOU   +3 more
doaj   +1 more source

Immunolocalization of Na+,K+-ATPase in the branchial cavity during the early development of the crayfish Astacus leptodactylus (Crustacea, Decapoda) [PDF]

Cell Tissue Res 319 (2005) 331-339, 2006
The ontogeny of osmoregulation was examined in the branchial cavity of embryonic and early post-embryonic stages of the crayfish Astacus leptodactylus maintained in freshwater, at the sub-cellular level through the detection of the sodium-potassium adenosine triphosphatase (Na(+),K(+)-ATPase).
arxiv   +1 more source

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

BMC Medicine, 2023
Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang   +13 more
doaj   +1 more source