Results 21 to 30 of about 1,153,497 (356)
Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
Nature Communications, 2018 A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of ...
Sophie Escot +4 more
doaj +1 more source
Communications Biology, 2022 Ho-Bouldoires, Sollier, Zamfirov and Broders-Bondon et al. show that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells through the mechanosensitive Ret kinase and that Ret activation is elevated in ...
Thanh Huong Nguyen Ho-Bouldoires +18 more
doaj +1 more source
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]
, 2006 Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R +4 more
core +2 more sources
Correlation with basic differentiation processes of neurons [PDF]
, 1991 The development of the spinal cord involves the proliferation of neurons, their migration to well-defined areas, fiber outgrowth and synapse formation. The present study was designed to correlate the spatiotemporal pattern of expression of synaptophysin,
Altman +37 more
core +2 more sources
Developmental potential of aneuploid human embryos cultured beyond implantation
Nature Communications, 2020 Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi +11 more
doaj +1 more source
Nature Communications, 2017 Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2 ...
Nuria Cerdá-Esteban +9 more
doaj +1 more source
The role of spatial averaging in the precision of gene expression patterns [PDF]
, 2009 During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations that diffusion
Erdmann, Thorsten +2 more
core +3 more sources
Current Biology, 2009 SummaryAs the UK updates its pioneering Human Fertilisation and Embryology Act, legal boundaries for research in the life sciences are redrawn in other countries as well. Michael Gross reports.
openaire +1 more source
Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation. [PDF]
, 2018 POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification.
Daigneault, Bradford W +3 more
core +2 more sources
FoxO1 in embryonic development [PDF]
Transcription, 2012 Establishment of the maternal-fetal circulation during embryonic development is a fundamental process required for effective exchange of nutrients, waste products and signaling factors critical to all subsequent stages of fetal growth and development.
Anwarul, Ferdous, Joseph A, Hill
openaire +2 more sources