Results 51 to 60 of about 481,310 (353)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A vector-based system for the differentiation of mouse embryonic stem cells toward germ-line cells [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):To culture thein vitro mouse embryonic stem cells (mESCs) and to direct their  differentiation to germ-line cells; in present study we used a vector backbone containing the fusion construct Stra8-EGFP to select differentiated ES cells that ...
Reza Ebrahimzadeh-Vesal, Mohammad Ali hokrgozar, Karim Nayernia, Ladan Teimoori-Toolabi, Mohammad Miryounesi, Seyedmehdi Nourashrafeddin, Najmeh Ranji, Mohammad Hosein Modarressi   +7 more
doaj  

2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

Stem Cell Reports, 2018
In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog ...
Pablo Navarro
doaj   +1 more source

Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]

, 2015
Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin, Gadegaard, Nikolaj, Hansson, Mattias, Holzmann Rasmussen, Camilla, McMeeking, Robert M., Petersen, Dorthe Roenn, Reynolds, Paul   +6 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Cell Reports, 2023
Summary: The RNA-binding protein Musashi-1 (MSI1) regulates the proliferation and differentiation of adult stem cells. However, its role in embryonic stem cells (ESCs) and early embryonic development remains poorly understood.
Youwei Chen, Ying Chen, Qianyan Li, Huahua Liu, Jiazhen Han, Hailin Zhang, Liming Cheng, Gufa Lin   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

LGR4 and LGR5 Function Redundantly During Human Endoderm DifferentiationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors for R-spondin proteins (Rspo 1, 2, 3, 4), and potentiate Wnt signaling in different contexts.
Yu-Hwai Tsai, David R. Hill, Namit Kumar, Sha Huang, Alana M. Chin, Briana R. Dye, Melinda S. Nagy, Michael P. Verzi, Jason R. Spence   +8 more
doaj   +1 more source

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson, Belotti D, Buske C, Deschamps J, Edwina Dobbin, Glenda J. Dickson, Helen Wheadon, Joanne M. Ramsey, Lawrence HJ, Pamela M. Corrigan, Robin W. Freeburn   +10 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source