Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review). [PDF]
Xiang JN +4 more
europepmc +1 more source
Understanding how cooperative interactions remain stable matters for biodiversity because many plants rely on specialist insects that can also impose reproductive costs. We studied the interaction between Sambucus sieboldiana and seed‐consuming Heterhelus beetles through detailed field observations and pollination experiments.
Suzu Kawashima +3 more
wiley +1 more source
Changes in egg structures during incubation and their relationship with hatchability and gosling quality in White Kołuda® and Biłgorajska geese. [PDF]
Wlaźlak S +6 more
europepmc +1 more source
Status and future of seed conservation of threatened plants in the post‐2020 era
Ambitious targets have been set to backup seeds of threatened plants by the global strategy for plant conservation (GSPC), but it is unclear in how far these targets have been met and how seed collection should be organized to meet future challenges. Here, we provide an overview of the status of 44 countries in achieving seed conservation targets.
Andreas Ensslin +130 more
wiley +1 more source
Stem cell transplantation in immuno-hematologic and infectious diseases. [PDF]
Mwita RP, Özdemir Ö.
europepmc +1 more source
COX5A promotes cell progression and cisplatin‐resistance and alleviates mitochondrial dysfunction. ISG15 shows a reversing role with COX5A. Targeting the COX5A‐mediated mitochondrial metabolic pathway may offer a novel therapeutic approach to enhance cisplatin sensitivity in HNSCC.
Nannan Guo +7 more
wiley +1 more source
Vitamin C Alleviates BPA Embryotoxicity by Attenuating Oxidative Stress and DNA Damage-Mediated Apoptosis via Modulation of the ATM/Chk2/p53 Pathway. [PDF]
Ren F +11 more
europepmc +1 more source
Photoperiod during incubation affects hatching performance, leg bone development and key gene expression in melanopsin mediated PLC-PKC pathway. [PDF]
Yu SZ +10 more
europepmc +1 more source
Green tea extract disrupts gonadal differentiation in a model avian system. [PDF]
Miller TM +3 more
europepmc +1 more source

