Results 91 to 100 of about 1,129,164 (264)

Seeding hESCs to achieve optimal colony clonality [PDF]

arXiv, 2019
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have promising clinical applications which often rely on clonally-homogeneous cell populations. To achieve this, cross-contamination and merger of colonies should be avoided. This motivates us to experimentally study and quantitatively model the growth of hESC colonies.
arxiv  

Identification and characterization of unique to human regulatory sequences in embryonic stem cells reveal associations with transposable elements, distal enhancers, non-coding RNA, and DNA methylation-driven mechanisms of genome editing [PDF]

arXiv, 2014
Despite significant progress in structural and functional characterization of human genome, understanding of mechanisms underlying the genetic basis of human phenotypic uniqueness remains limited. We report that non-randomly distributed transposable element-derived sequences, most notably HERV-H/LTR7 and L1HS, are associated with creation of 99.8 ...
arxiv  

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

Epigenetics
Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogenes or tumour suppressor genes, thus contributing to ...
Ji Ren, Xiuying Chen, Jing Li, Yuxin Zan, Shan Wang, Yujie Tan, Yan Ding   +6 more
doaj   +1 more source

CTCF Degradation Causes Increased Usage of Upstream Exons in Mouse Embryonic Stem Cells [PDF]

arXiv, 2018
Transcriptional repressor CTCF is an important regulator of chromatin 3D structure, facilitating the formation of topologically associating domains (TADs). However, its direct effects on gene regulation is less well understood. Here, we utilize previously published ChIP-seq and RNA-seq data to investigate the effects of CTCF on alternative splicing of ...
arxiv  

The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]

, 1992
Paul Hasty, Jaime A. Rivera‐Pérez, Allan Bradley   +2 more
openalex   +1 more source

Characterization of Kunitz-Domain Anticoagulation Peptides Derived from Acinetobacter baumannii Exotoxin Protein F6W77

Toxins
Recent studies have revealed that the coagulation system plays a role in mammalian innate defense by entrapping bacteria in clots and generating antibacterial peptides.
Fang Sun, Xiaolin Deng, Huanhuan Gao, Li Ding, Wen Zhu, Hongyi Luo, Xiangdong Ye, Xudong Luo, Zongyun Chen, Chenhu Qin   +9 more
doaj   +1 more source

Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1

Toxins
Viruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter.
Fang Sun, Xiangdong Ye, Tanran Han, Jingwen Xia, Lili Wu, Wen Zhu, Li Ding, Xudong Luo, Chenhu Qin, Zongyun Chen   +9 more
doaj   +1 more source

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Communications Biology
Chronic alcohol consumption can lead to alcohol live disease (ALD). Steatosis is a critical hallmark of ALD, making it an important stage for therapeutic intervention.
Mingzhu Jiang, Ying Feng, Jingxian Wang, Xiang Xu, Zegan Liu, Tongfei Li, Shinan Ma, Yufeng Wang, Xingrong Guo, Shiming Du   +9 more
doaj   +1 more source

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [PDF]

, 1990
Moshe Szyf, G Tanigawa, Philip L. McCarthy   +2 more
openalex   +1 more source

The ground state of embryonic stem cell self-renewal

Nature, 2008
Qi-Long Ying, Jason P. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, Austin G Smith   +7 more
semanticscholar   +1 more source