Results 101 to 110 of about 1,359,697 (399)

Modeling mammalian gastrulation with embryonic stem cells

, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
core   +1 more source

DNA methyltransferase-3-dependent nonrandom template segregation in differentiating embryonic stem cells. [PDF]

, 2013
Asymmetry of cell fate is one fundamental property of stem cells, in which one daughter cell self-renews, whereas the other differentiates. Evidence of nonrandom template segregation (NRTS) of chromosomes during asymmetric cell divisions in ...
Chen, Robert, Chooljian, Marc, CONBOY, Irina M, Conboy, Michael, Cousin, Wendy, Elabd, Christian, Pham, Joey   +6 more
core   +2 more sources

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Constraints to Progress in Embryonic Stem Cells from Domestic Species [PDF]

, 2013
Domestic animal embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Unfortunately, despite many efforts, validated embryonic stem cell lines in species other than mice and primates ...
Caamaño, J.N. (José), Díez, C., Gómez, E., Molina, I., Muñoz, M., Trigal, B.   +5 more
core  

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. [PDF]

, 2015
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.
A Kapoor, A Krapp, A Rada-Iglesias, A Sawada, A-C Binot, AF Hezel, AJ Saldanha, B Zhao, B Zhao, C Cortijo, C Haumaitre, C Trapnell, CHH Cho, CY McLean, DA Stoffers, DW Huang, E Kroon, E Rodríguez-Seguel, EF Chiang, F Argenton, F Esni, F Supek, FC Lynn, FC Pan, H Fang, H Fang, H Lango Allen, I Morán, I Rooman, J Bessa, J van Arensbergen, JM Oliver-Krasinski, K Kawakami, K Piper, K Piper, K Skouloudaki, KJ Gaulton, KM Petzold, KS Zaret, L Elghazi, L Pasquali, M Borowiak, M Carrasco, M Gannon, MA Maestro, MC Whitlock, MF Offield, MJL de Hoon, MN Weedon, MP Creyghton, N Bardeesy, N Gao, NM George, P Jacquemin, PA Seymour, R O’Rahilly, R Xie, RE Jennings, RF Luco, S Gupta, S Heinz, S Xuan, T Derrien, T Jowett, W Zhang, WA Whyte, Y Fujitani, Y Liu-Chittenden   +67 more
core   +2 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression

Cell Death and Disease
Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA in cancer.
Shanshan Qin, Qiwei Guo, Yue Liu, Xiangang Zhang, Pan Huang, Hedong Yu, Lingyun Xia, Weidong Leng, Dandan Li   +8 more
doaj   +1 more source

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

LINE-1 Based Insertional Mutagenesis Screens to Identify Genes Involved in Embryonic Stem Cell Differentiation

, 2016
Background: Knowledge of the intrinsic properties of embryonic stem cells is essential before the possibility of using these cells for therapeutic purposes becomes a reality. Insertional mutagenesis screens are widely used to identify genes sufficient to
Lee, Sung-Hun, Rangasamy, Danny
core   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source