Results 131 to 140 of about 1,359,697 (399)

Effect of 2D and 3D ECM and Biomechanical Cues on Human iPSC‐Derived Liver Progenitor Cell Differentiation

Advanced Healthcare Materials, EarlyView.
An engineered microtissue model is developed and optimized to investigate human liver development. Extracellular matrix composition and mechanical forces are tuned using high‐throughput assays. Human induced pluripotent stem cells serve as the cellular source, enabling the observation of de novo patterned differentiation.
Ishita Jain, Brock Grenci, Hyeon Ryoo, Yang Yuan, Salman R. Khetani, Gregory H. Underhill   +5 more
wiley   +1 more source

Indocyanine green-loaded platelet activated by photodynamic and photothermal effects for selective control of wound repair

Photodiagnosis and Photodynamic Therapy
Objective: Prompt and effective wound repair is an essential strategy to promote recovery and prevent infection in patients with various types of trauma.
Tian-Qi Ma, Nan-Nan Chen, Rong-Cheng Xiao, Qi-Rui Li, Meng-Yi Zhan, Chang-Long Gou, Jun Hu, Fan Leng, Liu-Gen Li, Ning Han, Hai-Tao Li, Xing-Chun Peng, Si-Yuan Chen, Xian-Yu Li, Tong-Fei Li   +14 more
doaj   +1 more source

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [PDF]

, 1990
Moshe Szyf, G Tanigawa, Philip L. McCarthy   +2 more
openalex   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis

Biology Direct
Background MicroRNA host gene (MIRHG) lncRNA is a particular lncRNA subclass that can perform both typical and atypical lncRNA functions. The biological function of MIRHG lncRNA MIR194-2HG in cancer is poorly understood.
Hong Cao, Zidi Wang, Qiwei Guo, Shanshan Qin, Dandan Li   +4 more
doaj   +1 more source

Triclosan induces pyroptosis by activation of the caspase-9/3/gasdermin E axis

Emerging Contaminants
The high concentrations of TCS in personal care products, and the potential for even greater exposure in occupational settings, raise significant concerns about its cytotoxic effects.
Shiqi Wu, Lei You, Shan He, Wenqaing Liu, Jinlin Lei, Jiahui Yang, Xiangyin Luo, Zhenxiu Ye, Yonghong Zhang, Jing Wang, Huailan Guo, Yan Zheng, Lanlan Zheng, Chen Li   +13 more
doaj   +1 more source

Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Engineered heart tissues (EHTs) are a valuable approach in capturing human cardiac physiology and drug responses in vitro. Here, a novel tapered pillar design is developed in an EHT platform to confine tissues in a predefined position‐ at the middle of the pillar height.
Milica Dostanić, Maury Wiendels, Laura M. Windt, Mervyn P.H. Mol, Francijna E. van den Hil, Richard P. Davis, Valeria Orlova, Berend J. van Meer, Massimo Mastrangeli, Christine L. Mummery   +9 more
wiley   +1 more source

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker [PDF]

, 1993
Marcelo Rubinstein, Miguel Á. Japón, Malcolm J. Low   +2 more
openalex   +1 more source

Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis

Advanced Healthcare Materials, EarlyView.
Radiotherapy damages bone and disrupts osteocyte function, yet mechanically mediated protection remains largely unexplored. This study demonstrates that low‐magnitude, high‐frequency (LMHF) vibration mitigates irradiated osteocyte apoptosis, restores their ability to regulate breast cancer extravasation, and acts synergistically with radiotherapy to ...
Xin Song, Kimberly Seaman, Amel Sassi, Chun‐Yu Lin, Tiankuo Chu, Liyun Wang, Yu Sun, Lidan You   +7 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source