Results 51 to 60 of about 1,293,017 (382)

Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins, 2023
Wasp stings have become an increasingly serious public health problem because of their high incidence and mortality rates in various countries and regions.
Xiangdong Ye, Xin Liu, Xudong Luo, Fang Sun, Chenhu Qin, Li Ding, Wen Zhu, Huajun Zhang, Haimei Zhou, Zongyun Chen   +9 more
doaj   +1 more source

The metabolome regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition

Nature Cell Biology, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Henrik Sperber, J. Mathieu, Yuliang Wang, A. Ferreccio, Jennifer Hesson, Zhuojin Xu, Karin A. Fischer, A. Devi, A. Devi, D. Detraux, Haiwei Gu, S. Battle, Megan Showalter, C. Valensisi, J. Bielas, J. Bielas, Nolan G. Ericson, L. Margaretha, A. Robitaille, D. Margineantu, O. Fiehn, O. Fiehn, D. Hockenbery, C. Blau, D. Raftery, D. Raftery, Adam A. Margolin, R. D. Hawkins, R. Moon, R. Moon, C. Ware, H. Ruohola-Baker   +31 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca, Enriquez, Jose, Kirby, Denise, Lightowlers, Robert, Rennie, Katherine, Smulders-Srinivasan, Tora, Trevelyan, Andrew, Turnbull, Doug, Whittington, Miles   +8 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Modeling mammalian gastrulation with embryonic stem cells

, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
core   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling

Scientific Reports
Small cell lung cancer (SCLC) is a therapeutically challenging disease. Metformin, an effective agent for the treatment of type 2 diabetes, has been shown to have antitumour effects on many cancers, including non-small cell lung cancer (NSCLC) and breast
Hong Xia, Xue-jiao Tai, Wang Cheng, Yi Wu, Dan He, Li-feng Wang, Hao Liu, Shen-yi Zhang, Yu-ting Sun, Hang-zhi Liu, Dan-dan Liu, Hu-zi Zhao, Fu-yun Ji, Xi-hua Li   +13 more
doaj   +1 more source