Results 51 to 60 of about 1,324,654 (403)

Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins, 2023
Wasp stings have become an increasingly serious public health problem because of their high incidence and mortality rates in various countries and regions.
Xiangdong Ye, Xin Liu, Xudong Luo, Fang Sun, Chenhu Qin, Li Ding, Wen Zhu, Huajun Zhang, Haimei Zhou, Zongyun Chen   +9 more
doaj   +1 more source

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.

European Heart Journal, 2015
AIMS Comparative studies suggest that stem cells committed to a cardiac lineage are more effective for improving heart function than those featuring an extra-cardiac phenotype.
P. Menasché, V. Vanneaux, A. Hagège, A. Bel, B. Cholley, Isabelle Cacciapuoti, Alexandre Parouchev, N. Benhamouda, G. Tachdjian, L. Tosca, J. Trouvin, J. Fabréguettes, V. Bellamy, R. Guillemain, C. Suberbielle Boissel, E. Tartour, M. Desnos, J. Larghero   +17 more
semanticscholar   +1 more source

Review of The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy (Basic Bioethics), edited by Suzanne Holland, Karen Lebacqz, and Laurie Zoloth [PDF]

, 2002
[Excerpt] Perhaps like others, I started The Human Embryonic Stem Cell Debate not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined.
Steele, James
core   +1 more source

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

The metabolome regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition

Nature Cell Biology, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Henrik Sperber, J. Mathieu, Yuliang Wang, A. Ferreccio, Jennifer Hesson, Zhuojin Xu, Karin A. Fischer, A. Devi, A. Devi, D. Detraux, Haiwei Gu, S. Battle, Megan Showalter, C. Valensisi, J. Bielas, J. Bielas, Nolan G. Ericson, L. Margaretha, A. Robitaille, D. Margineantu, O. Fiehn, O. Fiehn, D. Hockenbery, C. Blau, D. Raftery, D. Raftery, Adam A. Margolin, R. D. Hawkins, R. Moon, R. Moon, C. Ware, H. Ruohola-Baker   +31 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, EarlyView.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING

Frontiers in Pharmacology, 2022
The tumor-associated macrophage (TAM) serves as an immunosuppressive agent in the malignant tumor microenvironment, facilitating the development and metastasis of lung cancer.
Ting-Ting Yu, Ting-Ting Yu, Ting-Ting Yu, Ning Han, Ning Han, Ning Han, Liu-Gen Li, Liu-Gen Li, Xing-Chun Peng, Xing-Chun Peng, Qi-Rui Li, Qi-Rui Li, Hua-Zhen Xu, Xi-Yong Wang, Xi-Yong Wang, Zi-Yi Yang, Zi-Yi Yang, Xiao Chen, Mei-Fang Wang, Mei-Fang Wang, Tong-Fei Li, Tong-Fei Li, Tong-Fei Li   +22 more
doaj   +1 more source

Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells [PDF]

PLoS Comp Bio, 2010 Dec 16;6(12):e1001034, 2010
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but recent results point to a key role for epigenetic mechanisms.
arxiv   +1 more source