Results 51 to 60 of about 1,383,394 (337)

Clinical applications of stem cell-derived exosomes

Signal Transduction and Targeted Therapy
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation.
Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, K. Shahzad, Jialin C. Zheng   +5 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The lady vanishes: what's missing from the stem cell debate [PDF]

, 2006
Most opponents of somatic cell nuclear transfer and embryonic stem cell technologies base their arguments on the twin assertions that the embryo is either a human being or a potential human being, and that it is wrong to destroy a human being or ...
A. Fagot-Largeault, A. Jacobs, A. M. Honore, A. Ryan, C. A. MacKinnon, C. McLeod, C. Pateman, C. Waldby, CCNE (Comite Consultatif National d’Ethique), CCNE (Comite Consultatif National d’Ethique) and Nationaler Ethikrat. Opinion no. 77, D. B. Resnik, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, Donna L. Dickenson, E. Marshall, G. A. Cohen, G. Meilander, G. W. F. Hegel, HUGO (Human Genome Organisation) Ethics Council, I. Schneider, J. Boyle, J. E. Penner, J. E. Penner, J. L. Schroeder, J. Locke, J. Mahoney, J. McHale, J. Montgomery, J. W. Harris, J. Waldron, K. E. Ferguson, K. Momberger, L. Brace, M. J. Radin, R. Macklin, R. R Faden, Royal College of Obstetricians and Gynaecologists (RCOG) Ethics Committee, S. Dodds, S. E. Lanzendorf, S. Holland, S. Holm, T. Grey, T. Harrison, T. Murray, W. E. Connolly, W. S. Hwang   +50 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Characterisation of Embryonic Dermal Precursor Cells [PDF]

, 2018
Skin is an attractive organ for the acquisition of stem cells due to its accessibility, size and potential for autologous transplants. Research into skin development has implications for the isolation of stem cell populations, for example skin-derived ...
BLINCKO, SARAH
core  

A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells [PDF]

, 2016
Cell replacement and regenerative therapy using embryonic stem cell-derived material holds promise for the treatment of several pathologies. However, the safety of this approach is of prime importance given the teratogenic potential of residual stem ...
Choudhary, P, Whiting, PJ
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +1 more source

Embryonic Stem Cell Research as an Ethical Issue: On the Emptiness of Symbolic Value [PDF]

, 2001
The debate over human embryonic stem cell research-scientific and clinical prospects as well as ethical implications-became front-page news only after two teams of university researchers reported in November 1998 that they had isolated and cultured human
Quinn, Kevin P.
core   +2 more sources

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]

, 2020
Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon, Bustos, Francisco, Fernandez-Alonso, Rosalia, Findlay, Greg M., Helbig, Andreas O., Hukelmann, Jens, Kumar, Pankaj, Lamond, Angus I., Lanner, Fredrik, Petsalaki, Evangelia, Zhou, Houjiang   +10 more
core   +2 more sources