Results 51 to 60 of about 1,359,697 (399)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

MELK-a conserved kinase: functions, signaling, cancer, and controversy. [PDF]

, 2015
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.
Beullens, Monique, Ganguly, Ranjit, Kornblum, Harley I, Mohyeldin, Ahmed, Nakano, Ichiro, Thiel, Jordyn   +5 more
core   +2 more sources

The metabolome regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition

Nature Cell Biology, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Henrik Sperber, J. Mathieu, Yuliang Wang, A. Ferreccio, Jennifer Hesson, Zhuojin Xu, Karin A. Fischer, A. Devi, A. Devi, Damien Detraux, Haiwei Gu, S. Battle, Megan Showalter, C. Valensisi, J. Bielas, J. Bielas, Nolan G. Ericson, L. Margaretha, A. Robitaille, D. Margineantu, O. Fiehn, O. Fiehn, D. Hockenbery, C. Blau, D. Raftery, D. Raftery, Adam A. Margolin, R. D. Hawkins, R. Moon, R. Moon, C. Ware, H. Ruohola-Baker   +31 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy

Journal of Translational Medicine, 2023
Background Clinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of L-periaxin can be involved in CMT type 4F (CMT4F) by destroying the myelin sheath form, which may be related to ...
Ruo-nan Zhang, Xin Bao, Yun Liu, Yan Wang, Xing-Yuan Li, Ge Tan, Magdaleena Naemi Mbadhi, Wei Xu, Qian Yang, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu, Shan Li, Shao-juan Chen, Shi-you Chen, Jing Lv, Liu-liu Shi, Jun-ming Tang   +21 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway

Stem Cell Research & Therapy
Background Hyperglycemia and insulin resistance are among the key phenotypes of obesity and type 2 diabetes (T2DM). Notably, skeletal muscle fiber-type composition is closely linked to insulin resistance. Vascular endothelial growth factor B (VEGF-B) has
Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang   +17 more
doaj   +1 more source

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Cell Death and Disease, 2022
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1-
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin   +9 more
doaj   +1 more source

Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]

, 2008
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core  

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells [PDF]

, 2013
Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic ...
Inoue-Yokoo, Tomoko, Lai, Mei I., Lim, Wai Feng, Sugiyama, Daisuke, Tan, Keai Sinn   +4 more
core   +1 more source