Results 51 to 60 of about 566,277 (353)

VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway

Stem Cell Research & Therapy
Background Hyperglycemia and insulin resistance are among the key phenotypes of obesity and type 2 diabetes (T2DM). Notably, skeletal muscle fiber-type composition is closely linked to insulin resistance. Vascular endothelial growth factor B (VEGF-B) has
Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang   +17 more
doaj   +1 more source

The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

Cell Death and Disease, 2022
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that NR2F1-
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin   +9 more
doaj   +1 more source

Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]

, 2008
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling

Scientific Reports
Small cell lung cancer (SCLC) is a therapeutically challenging disease. Metformin, an effective agent for the treatment of type 2 diabetes, has been shown to have antitumour effects on many cancers, including non-small cell lung cancer (NSCLC) and breast
Hong Xia, Xue-jiao Tai, Wang Cheng, Yi Wu, Dan He, Li-feng Wang, Hao Liu, Shen-yi Zhang, Yu-ting Sun, Hang-zhi Liu, Dan-dan Liu, Hu-zi Zhao, Fu-yun Ji, Xi-hua Li   +13 more
doaj   +1 more source

Characterization of the Molecular Diversity and Degranulation Activity of Mastoparan Family Peptides from Wasp Venoms

Toxins, 2023
Wasp stings have become an increasingly serious public health problem because of their high incidence and mortality rates in various countries and regions.
Xiangdong Ye, Xin Liu, Xudong Luo, Fang Sun, Chenhu Qin, Li Ding, Wen Zhu, Huajun Zhang, Haimei Zhou, Zongyun Chen   +9 more
doaj   +1 more source

A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells [PDF]

, 2016
Cell replacement and regenerative therapy using embryonic stem cell-derived material holds promise for the treatment of several pathologies. However, the safety of this approach is of prime importance given the teratogenic potential of residual stem ...
Choudhary, P, Whiting, PJ
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Embryonic Stem Cell Research as an Ethical Issue: On the Emptiness of Symbolic Value [PDF]

, 2001
The debate over human embryonic stem cell research-scientific and clinical prospects as well as ethical implications-became front-page news only after two teams of university researchers reported in November 1998 that they had isolated and cultured human
Quinn, Kevin P.
core   +2 more sources

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells [PDF]

, 2013
Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic ...
Inoue-Yokoo, Tomoko, Lai, Mei I., Lim, Wai Feng, Sugiyama, Daisuke, Tan, Keai Sinn   +4 more
core   +1 more source