Results 61 to 70 of about 1,293,017 (382)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Produksi Embryonic Stem Cell (Esc) Line Dari Blastosis Mencit Dengan Metode Immunosurgery [PDF]

, 2014
Embryonic Stem Cells (ESC) are pluripotent stem cells which has the ablility to self renew and differentiate into form all cells in the body. Inner Cell Mass (ICM) as a source of ESC that can be obtained from blastocyst stage of embryos. Isolation can be
Rinendyaputri, R. (Ratih), Susanti, N. (Nike)   +1 more
core  

Micro- and nanoengineering approaches to control stem cell-biomaterial interactions. [PDF]

, 2011
As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem
Dokmeci, Mehmet R, Dolatshahi-Pirouz, Alireza, Khademhosseini, Ali, Kolind, Kristian, Nikkhah, Mehdi   +4 more
core   +2 more sources

Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING

Frontiers in Pharmacology, 2022
The tumor-associated macrophage (TAM) serves as an immunosuppressive agent in the malignant tumor microenvironment, facilitating the development and metastasis of lung cancer.
Ting-Ting Yu, Ting-Ting Yu, Ting-Ting Yu, Ning Han, Ning Han, Ning Han, Liu-Gen Li, Liu-Gen Li, Xing-Chun Peng, Xing-Chun Peng, Qi-Rui Li, Qi-Rui Li, Hua-Zhen Xu, Xi-Yong Wang, Xi-Yong Wang, Zi-Yi Yang, Zi-Yi Yang, Xiao Chen, Mei-Fang Wang, Mei-Fang Wang, Tong-Fei Li, Tong-Fei Li, Tong-Fei Li   +22 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics [PDF]

, 2012
Although stem cell fate is traditionally manipulated by exogenously altering the cells' extracellular signaling environment, the endogenous autocrine and paracrine signals produced by the cells also contribute to their two essential processes: self ...
Przybyla, Laralynne, Voldman, Joel
core   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway

Frontiers in Oncology, 2022
INPP4B (Inositol polyphosphate 4-phosphatase type II) has been regarded as a suppressor of several human tumors, but its biological function, expression, and clinical significance in glioma tissues and cell lines are unclear.
Xiaoming Sun, Xiaoming Sun, Xiaoming Sun, Yani Chen, Yani Chen, Yani Chen, Xiaoyang Tao, Xiaoyang Tao, Wenzi Zhang, Wenzi Zhang, Wenzi Zhang, Xinyu Wang, Xinyu Wang, Xinyu Wang, Xianhui Wang, Xianhui Wang, Zhihua Ruan, Zhuo Chen, Zhuo Chen, Zhuo Chen   +19 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source