Results 101 to 110 of about 5,338,715 (307)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development

Journal of Translational Medicine, 2011
In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy.
Ichim Thomas, Riordan Neil H, Stroncek David F   +2 more
doaj   +1 more source

Embryonic Stem Cell Research

Voices in Bioethics, 2019
Voices in Bioethics, Vol 5 (2019)
openaire   +2 more sources

Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells [PDF]

, 2012
Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but their collection is restricted ethically and technically.
Vanleene, Maximilien, George Bou-Gharios (139817), Moschidou Dafni, Gemma N Jones, Maximilien Vanleene (139811), George Bou-Gharios, Puga-Iglesias, Tamara-Isabel, Katarzyna Kuleszewicz, Sandra J. Shefelbine (139814), David, AL, Shefelbine, Sandra J., Fisk, NM, David Anna L., Moschidou, Dafni, Shefelbine Sandra J., Guillot, Pascale V., Bou-Gharios George, Gemma N. Jones (139797), Maximilien Vanleene, Fisk Nicholas M., Nicholas M Fisk, Shefelbine, SJ, De Coppi, Paolo, Puga-Iglesias, TI, Puga-Iglesias Tamara-Isabel, Katarzyna Kuleszewicz (139808), Paolo De Coppi (118582), Jones Gemma N., Bou-Gharios, G, Pascale V. Guillot (139827), Kuleszewicz Katarzyna, Anna L David, Vanleene, M, Kuleszewicz, K, David, Anna L., Sandra J Shefelbine, Fisk, Nicholas M., Dafni Moschidou, Paolo De Coppi, Bou-Gharios, George, Tamara-Isabel Puga-Iglesias, Pascale V Guillot, Jones, GN, Tamara-Isabel Puga-Iglesias (139805), Guillot, PV, De Coppi Paolo, Fisk, NM ; https://orcid.org/, Jones, Gemma N., Dafni Moschidou (139801), Guillot Pascale V., Kuleszewicz, Katarzyna, Moschidou, D, Vanleene Maximilien, Nicholas M. Fisk (139820), De Coppi, P, Anna L. David (139823)   +55 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Pig Pluripotent Stem Cells as a Candidate for Biomedical Application

Journal of Animal Reproduction and Biotechnology, 2019
Stem cells are progenitor cells that are capable of self-renewal and differentiation into various cells. Especially, pluripotent stem cells (PSCs) have in vivo and in vitro differentiation capacity into three germ layers and can proliferate infinitely ...
Kwang-Hwan Choi, Chang-Kyu Lee
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Network toxicology and molecular docking to investigate the mechanism of bisphenol A toxicity in human diabetic cardiomyopathy

Ecotoxicology and Environmental Safety
Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is widely used in polymers, plasticizers, and food packaging, raising significant concerns for human health. Growing evidence links BPA exposure to cardiovascular diseases, including diabetic
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
doaj   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source