Results 81 to 90 of about 5,338,715 (307)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Contribution of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells to Chimeras through Injection and Coculture of Embryos

Stem Cells International, 2014
Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected ...
Jitong Guo, Baojiang Wu, Shuyu Li, Siqin Bao, Lixia Zhao, Shuxiang Hu, Wei Sun, Jie Su, Yanfeng Dai, Xihe Li   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Vascular SMC-like CAF-derived THBS1 drives tumor-associated neutrophil recruitment to orchestrate an immunosuppressive microenvironment in gastric cancer

Cell Death and Disease
The immunosuppressive tumor microenvironment (TME) remains a primary barrier to effective immunotherapy. Tumor-associated neutrophils (TANs) are key contributors to this immunosuppressive landscape; however, the mechanisms governing their recruitment and
Dandan Li, Zeng Zhou, Yanyan Chen, Pan Huang, Lin Yuan, Qi Wang, Xiangang Zhang, Lantian Zhai, Xinqi Li, Lingyun Xia, Weidong Leng, Shanshan Qin   +11 more
doaj   +1 more source

Desaminotyrosine alleviates hepatic ischemia-reperfusion injury via the MAPK/ferroptosis axis and Bifidobacterium pseudolongum modulation

Pharmacological Research
Ischemia-reperfusion (I/R) is a common and unavoidable phenomenon during surgeries such as hepatectomy and liver transplantation, severely affecting patient prognosis. However, clinically intervention and treatment measures remain very limited.
Junyang Zhou, Man Luo, Ping Zhu, Yufang Zhu, Panpan Meng, Lin Chen, Liming Ma, Ying Li, Huizhong Liu, Yaqi Tian, Xinyi Zhang, Zhixiao Wang, Zhengjiang Cheng, Yijun Tang, Yan Ding   +14 more
doaj   +1 more source

Avian Embryonic Stem Cells [PDF]

, 2006
Blastodermal cells derived from the area pellucida of a stage X (EG&K) embryo have the potential to contribute to the somatic tissues and the germ line when reintroduced into a stage X (EG&K) recipient embryo. This chapter describes a method to culture chicken embryonic stem (cES) cells derived from blastodermal cells. Within the first week of culture,
Marie-Cecile, van de Lavoir, Christine, Mather-Love   +1 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Enhanced gene trapping in mouse embryonic stem cells [PDF]

, 2008
Gene trapping is used to introduce insertional mutations into genes of mouse embryonic stem cells (ESCs). It is performed with gene trap vectors that simultaneously mutate and report the expression of the endogenous gene at the site of insertion and ...
Hansen, J., von Melchner, H., Ruiz Noppinger, Patricia, Wurst, W., Schnütgen, Frank, Floss, Thomas, Hansen, Jens, Horn, C., Ruiz Noppinger, P., Horn, Carsten, Lutz, M., Lutz, Marcus, Schnütgen, F., De-Zolt, Silke, De-Zolt, S., Wurst, Wolfgang, Melchner, Harald von (Prof. Dr.), Floß, T.   +17 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source