Results 11 to 20 of about 506,868 (329)
Scientific Reports, 2021 In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral +3 more
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In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]
, 2014 Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique +13 more
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Loss of stem cell regenerative capacity within aged niches. [PDF]
, 2007 This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells.
Carlson, Morgan, CONBOY, Irina M
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Internal Medicine, 2001 Mouse embryonic stem (ES) cells are the cells that possess pluripotential differentiation activity into not only all somatic cells but also germ cells. Genetic alteration of mouse ES cells can be easily achieved and such genetic modification can be introduced into the animal, since ES cells are differentiated into germ cells in vivo.
Masatake Sato, Toru Nakano
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Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]
, 2009 Objectives: Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca +8 more
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Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment. [PDF]
PLoS ONE, 2017 The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes.
Shufeng Zhou +4 more
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Stem Cell Research, 2021 Marfan Syndrome (MFS) is a pleiotropic and autosomal dominant condition caused by pathogenic variants in FBN1. Although fully penetrant, clinical variability is frequently observed among patients and there are only few genotype-phenotype correlations ...
Juliana Borsoi +7 more
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Porcine OCT4 reporter system as a tool for monitoring pluripotency states
Journal of Animal Reproduction and Biotechnology, 2021 Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have naïve and primed pluripotent
Seung-Hun Kim, Chang-Kyu Lee
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Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]
, 2017 Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di +7 more
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Introducing embryonic stem cells [PDF]
Current Biology, 2001 The editors of Current Biology welcome correspondence on any article in the journal, but reserve the right to reduce the length of any letter to be published. All Correspondence containing data or scientific argument will be refereed. Items for publication should either be submitted typed, double-spaced to: The Editor, Current Biology, Elsevier Science
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