Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
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Neural tissue engineering using embryonic and induced pluripotent stem cells [PDF]
, 2011 With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural ...
Willerth, Stephanie M
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Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
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Modeling mammalian gastrulation with embryonic stem cells
, 2017 Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita +65 more
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]
, 2017 Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina +18 more
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The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development [PDF]
, 2011 In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy.
Ichim, Thomas +2 more
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Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]
, 2008 Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core
GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes +6 more
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Induced pluripotent stem cells derived from mouse germ cells [PDF]
, 2017 While embryonic stem cells are well known to give rise to tissues comprising all three germ layers, only recently was it found that embryonic-like stem cells could be derived from the postnatal mice testis in culture.
Khan, Nora
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Decatenation checkpoint deficiency in stem and progenitor cells [PDF]
, 2005 SummaryThe decatenation checkpoint normally delays entry into mitosis until chromosomes have been disentangled through the action of topoisomerase II.
Bestor, Timothy H. +3 more
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