Results 31 to 40 of about 5,338,715 (307)

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom, Burdon, T., Smith, A., Savatier, Pierre, Smith, Austin   +4 more
core   +1 more source

Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]

, 2006
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Joanne Crossley, Crossley, J., Andrew Godfrey, Takeuchi, Y., Clements, M.O., Boshoff, C., Godfrey, A., Mark O. Clements, Sam J. Wilson, Wilson, S.J., Yasu Takeuchi, Chris Boshoff   +11 more
core   +1 more source

Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]

, 2011
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis.
St John, Justin, Kelly, Richard, Kelly, RDW, Stuart Egginton, Rae, Peter, Richard DW Kelly, StJohn, JC, Peter C Rae, St. John, Justin C., Justin C St John, Rae, Peter C., Egginton, Stuart, Rae, PC, Egginton, S, Kelly, Richard D. W., St John, JC   +15 more
core   +1 more source

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
core   +1 more source

Stem cells in the embryonic kidney [PDF]

Kidney International, 2008
The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two precursor tissues, the metanephric mesenchyme and the ureteric bud. The ureteric bud induces the metanephric mesenchyme to differentiate into the epithelia of glomeruli and renal tubules.
openaire   +2 more sources

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]

, 2010
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S., Nicole M. Kane, Fergus R. McKenzie, Kane, N.M., Achamma Abraham, George S. Baillie, Allcock, R.W., John McAbney, Peter Burton, Baillie, G.S., Graeme Milligan, Kane, Nicole M., Houslay, Miles D., Andrew H. Baker, Robert W. Allcock, Gilmour, J., Gilmour, Jane, Mountford, Joanne C., Joanne C. Mountford, Jiang, Zhong, Miles D. Houslay, Adams, D.R., Adams, David R., McAbney, J., McCahill, Angela, Milligan, Graeme, McKenzie, F.R., Burton, Peter, Abraham, Achamma, Baker, Andrew H., McCahill, A., Jane Gilmour, Jiang, Z., Baker, A.H., Mountford, J.C., Angela McCahill, Abraham, A., Houslay, M.D., McAbney, John, McKenzie, Fergus R., Burton, P., David R. Adams, Milligan, G., Allcock, Robert W., Zhong Jiang   +44 more
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Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells

Stem Cells International, 2016
Rybp (Ring1 and Yy1 Binding Protein) is a transcriptional regulator and member of the noncanonical polycomb repressive complex 1 with essential role in early embryonic development.
Gergo Kovacs, Viktoria Szabo, Melinda K. Pirity   +2 more
doaj   +1 more source

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier, Fischer, Bruno,, Sommer, Lukas, Sommer, Lukas,, Draganova, Kalina,, Draganova, Kalina, Fischer, Bruno, Cantu, Claudio, Azim, Kasum,, Butt, Arthur, Raineteau, Olivier,, Butt, Arthur,, Azim, Kasum, Hurtado-Chong, Anahi,, Hurtado-Chong, Anahi, Cantù, Claudio,, Zemke, Martina, Zemke, Martina,   +17 more
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Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Smulders-Srinivasan, T. K., Turnbull, Doug, Trevelyan, Andrew, Smulders-Srinivasan, Tora, Rennie, Katherine, Acin-Perez, Rebecca, Enriquez, J. A., Rennie, K. J., Lightowlers, R. N., Smulders-Srinivasan, T. K.; id_orcid, Kirby, D. M., Whittington, M., Trevelyan, A. J., Turnbull, D. M., Acin-Perez, R., Kirby, Denise, Lightowlers, Robert, Whittington, Miles, Enriquez, Jose   +18 more
core   +1 more source

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment. [PDF]

PLoS ONE, 2017
The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes.
Shufeng Zhou, Mohamed Abdouh, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena   +4 more
doaj   +1 more source