Results 251 to 260 of about 565,140 (354)

Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells

, 2015
Yan Jin, Jianing Cao, Xin Xu, Xinhe Ye, Ying Chen, Jun Yang, Qiuting Feng, Li Zhu, Qian Xi, Chengjian Yang   +9 more
openalex   +2 more sources

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

RNA-Seq dataset of wild type and PRC2 mutant mouse embryonic stem cells undergoing ground state conversion. [PDF]

Data Brief
Chapa CM, Fetch DR, Jumamyradova AA, Soshnev AA.   +3 more
europepmc   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells. [PDF]

FEBS Open Bio
Amel A, Brown R, Rabeling A, Goolam M.
europepmc   +1 more source

Decision letter: Non-canonical TAF complexes regulate active promoters in human embryonic stem cells

, 2012

openalex   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses. [PDF]

Nat Commun
Dong H, Pan Z, Jiao P, Ye F, Peng Q, Yu Y, Lai X, Li H, Guan Z, Deng J, Shen T, Tan W, Shi Y, Ding Q, Luo J, Li T, Zhuang H, Xiang K.   +17 more
europepmc   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Regulation of PKCi-mediated pluripotency and gene expression by polycomb complex 1 in mouse embryonic stem cells. [PDF]

Am J Transl Res
Wu F, Liu Z, Wu X, Li J, Chen X, Yang L, Du F.   +6 more
europepmc   +1 more source