Results 41 to 50 of about 571,903 (350)

Behind the developing brains and beating hearts of stem cell-derived embryo models

Open Biology, 2023
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development.
Gianluca Amadei, David M. Glover
doaj   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

Effects of Alkaline Phosphatase, GATA, and BMP Expression on Three Populations of Cells: Spermatogonial Stem Cells, Embryonic Cells, and Embryonic Stem-Like Cells in Mice [PDF]

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Alkaline phosphatase, BMP, and GATA proteins are important factors in the process of spermatogenesis. This study aims to investigate the effect of alkaline phosphatase, GATA, and BMP expression on spermatogenic stem cells ...
Emad Reza, Hossein Azizi
doaj  

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

ABI3BP promotes renal aging through Klotho-mediated ferroptosis

Journal of Translational Medicine
The aging process of the kidneys is accompanied with several structural diseases. Abnormal fiber formation disrupts the balance of kidney structure and function, causing to end-stage renal disease and subsequent renal failure.
Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang, Yan Ding   +8 more
doaj   +1 more source

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca, Enriquez, Jose, Kirby, Denise, Lightowlers, Robert, Rennie, Katherine, Smulders-Srinivasan, Tora, Trevelyan, Andrew, Turnbull, Doug, Whittington, Miles   +8 more
core   +2 more sources

Embryonic Stem Cell Research

Voices in Bioethics, 2019
Voices in Bioethics, Vol 5 (2019)
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Trimethylamine N-oxide promotes the proliferation and migration of hepatocellular carcinoma cell through the MAPK pathway

Discover Oncology
Trimethylamine-n-oxide (TMAO) is a metabolite of intestinal flora following the consumption of phosphatidylcholine-rich foods. Clinical cohort studies have shown that plasma TMAO may be a risk factor for cancer development, including hepatocellular ...
Chunfang Zhou, Rina Basnet, Chenxiang Zhen, Shinan Ma, Xingrong Guo, Zhongxia Wang, Yahong Yuan   +6 more
doaj   +1 more source

Porcine pluripotent stem cells: progress, challenges and prospects [PDF]

Frontiers of Agricultural Science and Engineering, 2019
Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multiple differentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.
Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU
doaj   +1 more source