Results 41 to 50 of about 1,367,138 (398)

A Sweet Potion to Put Embryonic Stem Cells to Sleep

The Scientific World Journal, 2009
Human embryonic stem cells (hESCs) are rapidly revolutionizing the areas of drug screening and therapy. In view of their applications and high operational costs at global multicentric setups, the ability to store and transport hESCs and derivatives under
Kaushik D. Deb
doaj   +1 more source

Stem Cells from a Biological Perspective in Animals: A Review [PDF]

, 2017
Cells are the smallest living units of living system. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce more stem cells.
Jain, A. (Archana), Khan, M. A. (M), Shakkarpude, J. (J)   +2 more
core   +1 more source

Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]

, 2018
A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A, Fan, Yuhong, Kumar, Ashwath, Lin, Zhiqiang, Madfis, Nicole, McCloskey, Kara E, Platt, Manu O   +6 more
core   +1 more source

Behind the developing brains and beating hearts of stem cell-derived embryo models

Open Biology, 2023
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development.
Gianluca Amadei, David M. Glover
doaj   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

Effects of Alkaline Phosphatase, GATA, and BMP Expression on Three Populations of Cells: Spermatogonial Stem Cells, Embryonic Cells, and Embryonic Stem-Like Cells in Mice [PDF]

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Alkaline phosphatase, BMP, and GATA proteins are important factors in the process of spermatogenesis. This study aims to investigate the effect of alkaline phosphatase, GATA, and BMP expression on spermatogenic stem cells ...
Emad Reza, Hossein Azizi
doaj  

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Acin-Perez, Rebecca, Enriquez, Jose, Kirby, Denise, Lightowlers, Robert, Rennie, Katherine, Smulders-Srinivasan, Tora, Trevelyan, Andrew, Turnbull, Doug, Whittington, Miles   +8 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

ABI3BP promotes renal aging through Klotho-mediated ferroptosis

Journal of Translational Medicine
The aging process of the kidneys is accompanied with several structural diseases. Abnormal fiber formation disrupts the balance of kidney structure and function, causing to end-stage renal disease and subsequent renal failure.
Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang, Yan Ding   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source