Results 131 to 140 of about 2,310 (177)

Embryotoxicity of the pesticide mirex in vitro

Teratogenesis, Carcinogenesis, and Mutagenesis, 2002
AbstractMirex is a pesticide that is environmentally stable, accumulates in body tissues, and is embryo‐ and feto‐toxic at high concentrations in vivo. This study is the first to evaluate the effects of mirex on organogenesis‐stage embryos in vitro. Mouse embryos were exposed on gestation day 8.5 for 24 h in whole‐embryo culture to mirex at 100, 200 ...
Ahmed A, El-Bayomy, Ida W, Smoak, Stacy, Branch   +2 more
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Cyclosporin-Induced Embryotoxicity in Mice

Biology of the Neonate, 2009
Pregnant ICR mice were injected daily with 30 mg cyclosporin (CS)/kg body weight on days 6–8 or 10–12 of gestation. In parallel, control mice were administered saline injections on the same gestational days. The mice were sacrificed on days 12, 15, 17 or 19 of gestation.
A, Fein, M, Vechoropoulos, L, Nebel
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Studies of mitochondria in oxidative embryotoxicity

Teratology, 1995
AbstractWhile the limb bud and brain of the rat develop abnormally in response to transient uteroplacental hypoperfusion during late gestation, the heart appears to be protected. These malformations have been associated with the generation of reactive oxygen species (ROS). Studies were designed to examine superoxide generation by mitochondrial electron
A G, Fantel, R E, Person, R W, Tumbic, T D, Nguyen, B, Mackler   +4 more
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Embryotoxicity of chemical contaminants of foods

Food and Cosmetics Toxicology, 1971
Abstract A brief review of a variety of contaminants that may occur in foodstuffs indicates that in the majority of cases embryotoxicity or teratogenicity are toxic hazards unlikely to arise in practice as a result of such contamination. The major possible exception is mercury especially methylmercury, on which further data are being obtained ...
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Combined Fertility and Embryotoxicity Study

2012
Under normal circumstances, fertility and embryotoxicity studies are run separately according to the ICH S5(R2) guideline for the detection of toxicity to reproduction of medicinal products (1). However, the flexible approach of the S5(R2) guideline also allows the reproduction stages covered in the fertility and embryo-fetal development studies ...
Lucie, Reynaud, Edward, Marsden
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The Embryotoxic and Immunodepressive Effects of Gossypol

The American Journal of Chinese Medicine, 1986
The effects of gossypol acetic on pregnancy, embryofoetal development and on some selected parameters of immunological response in mice were studied. Daily intragastric administration of gossypol (50 or 75 mg/kg/day) during day 1-15 of gestation in mice produced a dose-dependent embroyocidal effect (37.8% and 94.5% respectively) of non-viable foetuses.
G.M. Sein, M. Phil
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Studies on the embryotoxicity and mutagenicity of mycotoxins

Mycotoxin Research, 1986
Embryotoxicity: Aflatoxin B1(AFB1), G1 (AFG1), and Patulin (PA) were investigated in NMRI mice for embryotoxic and teratogenic activity. These three mycotoxins were injected intraperitoneally or given orally on day 12 and 13 of pregnancy. AFB1 (15, 45, and 90 mg/kg ip or 45 mg/kg po) produced a moderate retardation in the fetal development and a dose ...
G, Matthiaschk, A, Korte
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Embryotoxicity and teratogenicity of Cis-diamminedichloroplatinum

Experientia, 1979
Cis-diamminedichloroplatinum has lethal, toxic and teratogenic effects on presomitic mouse embryos in doses that are not toxic to adult animals.
R, Lazar, P C, Conran, I, Damjanov
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The embryotoxic and osteolathyrogenic effects of semicarbazide

Toxicology, 1985
The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development.
T W, Schultz, J N, Dumont, R G, Epler
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In vitro embryotoxicity and teratogenicity studies

Toxicology in Vitro, 1990
During the past decade many publications have appeared describing test methods for in vitro toxicological research and emphasizing their desirability, appropriations and necessity. One reason for this might be the pressure imposed on regulatory, industrial and academic communities by society to reduce the number of animals used in research and testing ...
Peters, PWJ, Piersma, AH
openaire   +3 more sources