Results 121 to 130 of about 2,310 (177)
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American Journal of Obstetrics and Gynecology, 1977
Intraperitoneal injection of bilirubin in a dosage of 25 mg. per kilogram during the days nine to 15 of gestation in bile duct-ligated heterozygous Gunn rats was embryotoxic. Bile duct ligation per se had no gross observable effects on fetal development.
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Intraperitoneal injection of bilirubin in a dosage of 25 mg. per kilogram during the days nine to 15 of gestation in bile duct-ligated heterozygous Gunn rats was embryotoxic. Bile duct ligation per se had no gross observable effects on fetal development.
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Embryotoxicity of betel nuts in mice
Toxicology, 1985The fetotoxic potential of betel nuts was investigated in Swiss albino mice. Total aqueous extracts of ripe betel nuts of unprocessed and processed varieties were administered to pregnant animals at dose levels of 1, 3 and 5 mg/day/mouse (27 +/- 1 g body wt) through days 6-15 of gestation.
A, Sinha, A R, Rao
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Teratogenicity and embryotoxicity of some maleinimides
Archives of Toxicology, 1976Maleinimide, the teratogenic structural "central part" of the thalidomide molecule, and 5 of its dichloro- and dibromo-derivatives have been investigated teratologically by tests on SWS mice. According to both the electrophilic properties and the spatial requirements of the substituents, the effects were found to be up to 100 times stronger than those ...
K, Fickentscher, F, Köhler
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Embryotoxicity of meglumine antimoniate in the rat
Reproductive Toxicology, 2001Meglumine antimoniate (MA) is a pentavalent antimonial (Sb(V)) drug used to treat leishmaniasis. Despite the fact that Sb(V) organic compounds have been used in clinical practice for more than 50 years, information on their safety during pregnancy is still scanty. This study was undertaken to evaluate the embryo/fetotoxicity of MA in the rat.
F J, Paumgartten, I, Chahoud
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Marihuana-Induced Embryotoxicity in the Rabbit
Toxicological Sciences, 1986Few teratogenic studies in animals have been performed simulating marihuana smoking in man. An inhalation marihuana teratology study was conducted in albino rabbits utilizing a modified automatic smoking machine originally developed for rats and mice. Appropriate numbers of dams were exposed to 4 puffs (0.14 mg/kg), 8 puffs (0.72 mg/kg), or 16 puffs (1.
H, Rosenkrantz +3 more
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Embryotoxicity of lead onBufo arenarum
Bulletin of Environmental Contamination and Toxicology, 1988Lead, one of the oldest and more widely distributed pollutants, produces serious toxicological effects. From an ecotoxicological point of view, amphibians are useful as indicators of environmental contamination because they are sensitive to a great variety of toxic agents.
C S, Pérez-Coll +2 more
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Embryotoxicity of cisplatin in rats and mice
Toxicology and Applied Pharmacology, 1983Cisplatin [cis-dichlorodiammineplatinum (II)], a broad spectrum antitumor agent, was tested for possible teratogenic and embryolethal effects on Wistar rats and Swiss Webster mice. Rats were given a single ip injection of 0.3, 1.0, 2.5, or 3.0 mg/kg cisplatin on Day 6, 8, 11, or 14 of gestation, whereas mice were given a single ip injection of 0.3, 3.0,
K A, Keller, S K, Aggarwal
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EMBRYOTOXICITY OF PHOMOPSIN IN RATS
Australian Journal of Experimental Biology and Medical Science, 1983SummaryThe effect of phomopsin, the mycotoxin of Phomopsis leptostromiformis responsible for lupinosis, was examined in pregnant rats and their embryos. A Single injection at the rate of 0·025–0·4 mg/kg was administered on days 6, 8, 10, 12 or 14 of pregnancy or repeated Injections at the daily rate of 0·03 or 0· 09 mg/kg were given on days 6·10 or 11 ...
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Embryotoxic Effect of L-Asparaginase
Nature, 1968L-Asparaginase catalyses the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Interest in this enzyme has been stimulated by the discovery that it inhibits the growth of several experimental tumours1–3. L-Asparaginase is being used clinically to treat various leukaemias, lymphomas arid melanomas4, and it was recently shown to inhibit the ...
R H, Adamson, S, Fabro
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Embryotoxicity and teratogenicity of thalidomide in rats
Teratology, 1983AbstractThe teratogenicity of thalidomide in Wistar rats was investigated after a single maternal intravenous injection during the organogenetic period. Thalidomide was administered at 45 mg/kg in 0.5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy.
M, Parkhie, M, Webb
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