Results 171 to 180 of about 4,182 (225)

Embryotoxicity of lead onBufo arenarum

Bulletin of Environmental Contamination and Toxicology, 1988
Lead, one of the oldest and more widely distributed pollutants, produces serious toxicological effects. From an ecotoxicological point of view, amphibians are useful as indicators of environmental contamination because they are sensitive to a great variety of toxic agents.
C S, Pérez-Coll, J, Herkovits, A, Salibián   +2 more
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Embryotoxicity of betel nuts in mice

Toxicology, 1985
The fetotoxic potential of betel nuts was investigated in Swiss albino mice. Total aqueous extracts of ripe betel nuts of unprocessed and processed varieties were administered to pregnant animals at dose levels of 1, 3 and 5 mg/day/mouse (27 +/- 1 g body wt) through days 6-15 of gestation.
A, Sinha, A R, Rao
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Teratogenicity and embryotoxicity of some maleinimides

Archives of Toxicology, 1976
Maleinimide, the teratogenic structural "central part" of the thalidomide molecule, and 5 of its dichloro- and dibromo-derivatives have been investigated teratologically by tests on SWS mice. According to both the electrophilic properties and the spatial requirements of the substituents, the effects were found to be up to 100 times stronger than those ...
K, Fickentscher, F, Köhler
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Embryotoxicity of cisplatin in rats and mice

Toxicology and Applied Pharmacology, 1983
Cisplatin [cis-dichlorodiammineplatinum (II)], a broad spectrum antitumor agent, was tested for possible teratogenic and embryolethal effects on Wistar rats and Swiss Webster mice. Rats were given a single ip injection of 0.3, 1.0, 2.5, or 3.0 mg/kg cisplatin on Day 6, 8, 11, or 14 of gestation, whereas mice were given a single ip injection of 0.3, 3.0,
K A, Keller, S K, Aggarwal
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EMBRYOTOXICITY OF PHOMOPSIN IN RATS

Australian Journal of Experimental Biology and Medical Science, 1983
SummaryThe effect of phomopsin, the mycotoxin of Phomopsis leptostromiformis responsible for lupinosis, was examined in pregnant rats and their embryos. A Single injection at the rate of 0·025–0·4 mg/kg was administered on days 6, 8, 10, 12 or 14 of pregnancy or repeated Injections at the daily rate of 0·03 or 0· 09 mg/kg were given on days 6·10 or 11 ...
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Embryotoxic Effect of L-Asparaginase

Nature, 1968
L-Asparaginase catalyses the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Interest in this enzyme has been stimulated by the discovery that it inhibits the growth of several experimental tumours1–3. L-Asparaginase is being used clinically to treat various leukaemias, lymphomas arid melanomas4, and it was recently shown to inhibit the ...
R H, Adamson, S, Fabro
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Embryotoxicity and teratogenicity of thalidomide in rats

Teratology, 1983
AbstractThe teratogenicity of thalidomide in Wistar rats was investigated after a single maternal intravenous injection during the organogenetic period. Thalidomide was administered at 45 mg/kg in 0.5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy.
M, Parkhie, M, Webb
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Embryotoxicity of the pesticide mirex in vitro

Teratogenesis, Carcinogenesis, and Mutagenesis, 2002
AbstractMirex is a pesticide that is environmentally stable, accumulates in body tissues, and is embryo‐ and feto‐toxic at high concentrations in vivo. This study is the first to evaluate the effects of mirex on organogenesis‐stage embryos in vitro. Mouse embryos were exposed on gestation day 8.5 for 24 h in whole‐embryo culture to mirex at 100, 200 ...
Ahmed A, El-Bayomy, Ida W, Smoak, Stacy, Branch   +2 more
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Combined Fertility and Embryotoxicity Study

2012
Under normal circumstances, fertility and embryotoxicity studies are run separately according to the ICH S5(R2) guideline for the detection of toxicity to reproduction of medicinal products (1). However, the flexible approach of the S5(R2) guideline also allows the reproduction stages covered in the fertility and embryo-fetal development studies ...
Lucie, Reynaud, Edward, Marsden
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Cyclosporin-Induced Embryotoxicity in Mice

Biology of the Neonate, 2009
Pregnant ICR mice were injected daily with 30 mg cyclosporin (CS)/kg body weight on days 6–8 or 10–12 of gestation. In parallel, control mice were administered saline injections on the same gestational days. The mice were sacrificed on days 12, 15, 17 or 19 of gestation.
A, Fein, M, Vechoropoulos, L, Nebel
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