Results 1 to 10 of about 13,374 (270)

Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences [PDF]

Molecular Biomedicine, 2020
The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically used “old” drugs have been repurposed to this new disease for the urgent clinical investigation ...
Aoli Wang, Yong Sun, Qingwang Liu, Hong Wu, Juan Liu, Jun He, Junling Yu, Qing Qing Chen, Yinglu Ge, Zhuhui Zhang, Chen Hu, Cheng Chen, Ziping Qi, Fengming Zou, Feiyang Liu, Jie Hu, Ming Zhao, Tao Huang, Beilei Wang, Li Wang, Wei Wang, Wenchao Wang, Tao Ren, Jing Liu, Yehuan Sun, Song Fan, Qibing Wu, Chaozhao Liang, Liangdan Sun, Bin Su, Wei Wei, Qingsong Liu   +31 more
doaj   +3 more sources

Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study

Journal of Bio-X Research, 2021
. Objective:. Emetine, an isoquinoline alkaloid that is enriched at high concentrations in the lung, has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Song Fan, Qi Zhen, Cheng Chen, Wenjun Wang, Qibing Wu, Huihui Ma, Chengyuan Zhang, Li Zhang, Baojing Lu, Huiyao Ge, Liang Yong, Bao Li, Yafen Yu, Weiwei Chen, Yiwen Mao, Guangbo Qu, Li Su, Aoli Wang, Zhen Ding, Haiwen Li, Jin Zhang, Yonglian Wang, Yufeng Gao, Xihai Xu, Zhongming Zhu, Jun Chen, Long Zhang, Hongqiang Liang, Song Wu, Meng Huang, Quan Xia, Ping Li, Yehuan Sun, Chaozhao Liang, Wei Wei, Qingsong Liu, Liangdan Sun   +36 more
doaj   +3 more sources

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells [PDF]

Cell Death Discovery
Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra   +12 more
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Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]

PLoS ONE, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews, Jon Deakin, May Rajab, Maryam Idris-Usman, Niroshini J Nirmalan   +4 more
doaj   +9 more sources

Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses

Pharmaceuticals, 2020
The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
Martin D. Bleasel, Gregory M. Peterson
doaj   +2 more sources

Unveiling FOS as a Potential Diagnostic Biomarker and Emetine as a Prospective Therapeutic Agent for Diabetic Nephropathy

Journal of Inflammation Research, 2023
Jiaqiong Lin,1 Xiaoyong Li,2 Yan Lin,3 Zena Huang,3 Fei He,4 Fu Xiong4,5 1Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan, People’s Republic of China; 2General Surgery ...
Lin J, Li X, Lin Y, Huang Z, He F, Xiong F   +5 more
doaj   +2 more sources

Emetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2

Pharmaceuticals, 2020
Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity.
Martin D. Bleasel, Gregory M. Peterson
doaj   +2 more sources

Application of emetine in SARS-CoV-2 treatment: regulation of p38 MAPK signaling pathway for preventing emetine-induced cardiac complications

Cell Cycle, 2022
Emetine is one of the most highly potent anti-SARS-CoV-2 agents ever identified. In addition to having strong anti-SARS-CoV-2 activities, emetine has other valuable therapeutic effects such as strong anti-inflammatory and anti-arterial pulmonary ...
Mehdi Valipour, Hamid Irannejad, Saeed Emami   +2 more
openalex   +3 more sources

Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses

BMC Cancer, 2022
Background Patients with lung adenocarcinoma (LUAD) may be more predisposed to coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still a lack of effective anti-LUAD/COVID-19 drugs.
Kun Zhang, Ke Wang, Chaoguo Zhang, Xiuli Teng, Dan Li, Mingwei Chen   +5 more
doaj   +2 more sources

Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies

Journal of Biomolecular Structure and Dynamics, 2021
The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches.
Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri, Emira Noumi   +9 more
openalex   +3 more sources