Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer [PDF]
Molecular OncologyAnaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK.
Sang‐Min Park +8 more
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CD40LG as a Biomarker in Rheumatoid Arthritis: Links to Bone Destruction and Interstitial Lung Disease ‐ A Bioinformatic Analysis With Clinical Validation [PDF]
Health Science ReportsBackground and Aims Biomarkers are essential tools in the diagnosis and management of various diseases. Rheumatoid arthritis (RA) is a systemic inflammatory disorder that frequently results in damage to joints and organs.
Chuanhui Yao +10 more
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Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice [PDF]
Molecular Medicine, 2016 Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the pathogenesis of hyperglycemia in NOD murine ...
LaQueta K Hudson +20 more
doaj +2 more sources
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. [PDF]
PLoS Pathogens, 2016 Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified emetine
Rupkatha Mukhopadhyay +14 more
doaj +2 more sources
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments [PDF]
Life Science Alliance, 2022 This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis.
Dávid Lukáč +2 more
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Emetine and cephaeline content in plants of Psychotria ipecacuanha in Costa Rica
Revista Colombiana de Química, 2020 The objective of this study was to identify the emetic metabolites in different parts of the P. ipecacuanha, a plant with emetic properties. Partial phytochemical analysis was performed to determine the presence of emetine and cephaeline in leaves, stems
María Catalina Rosales López +2 more
doaj +2 more sources
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Viruses, 2019 Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases.
Petter I. Andersen +14 more
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Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity [PDF]
Molecules, 2015 Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
Ana Luiza Chaves Valadão +6 more
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Emetine reduces the effective dose of cisplatin or carboplatin required to inhibit bladder cancer cell proliferation [PDF]
Bladder, 2017 OBJECTIVE: We analyzed a novel therapeutic combination of emetine dihydrochloride added to standard of care chemotherapeutic agents (cisplatin, carboplatin, gemcitabine) in human muscle-invasive bladder cancer cell lines to determine if emetine enhanced ...
Valerie Davidson +4 more
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Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]
PLoS Pathogens, 2018 Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny +4 more
doaj +2 more sources