Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer [PDF]
Molecular OncologyAnaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK.
Sang‐Min Park +8 more
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CD40LG as a Biomarker in Rheumatoid Arthritis: Links to Bone Destruction and Interstitial Lung Disease ‐ A Bioinformatic Analysis With Clinical Validation [PDF]
Health Science ReportsBackground and Aims Biomarkers are essential tools in the diagnosis and management of various diseases. Rheumatoid arthritis (RA) is a systemic inflammatory disorder that frequently results in damage to joints and organs.
Chuanhui Yao +10 more
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Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. [PDF]
PLoS Pathogens, 2016 Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified emetine
Rupkatha Mukhopadhyay +14 more
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Structure and Biogenesis of Emetine [PDF]
Nature, 1948 IN making favourable comment on Woodward‘s ingenious suggestion respecting the biogenesis of strychnine1, the hope was expressed that further speculation of a similar kind would be based on a comparable “degree of coincidence”. The remarkable development mentioned below certainly meets this requirement. It provides an outstanding example of interaction
Robert Robinson
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Emetine and cephaeline content in plants of Psychotria ipecacuanha in Costa Rica
Revista Colombiana de Química, 2020 The objective of this study was to identify the emetic metabolites in different parts of the P. ipecacuanha, a plant with emetic properties. Partial phytochemical analysis was performed to determine the presence of emetine and cephaeline in leaves, stems
María Catalina Rosales López +2 more
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Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations [PDF]
Virus ResearchThe emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko +24 more
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Emetine Synergizes with Cisplatin to Enhance Anti-Cancer Efficacy against Lung Cancer Cells [PDF]
International Journal of Molecular Sciences, 2019 Cisplatin is still the primary therapeutic choice for advanced lung cancers without driver mutations. The occurrence of cisplatin resistance is a major clinical problem in lung cancer treatment.
Ti-Hui Wu +5 more
semanticscholar +2 more sources
Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]
PLoS Pathogens, 2018 Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny +4 more
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THE EFFECTS OF EMETINE ON THE HEART [PDF]
Heart, 1945 J. D. Cottrell, G. W. Hayward
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Molecules, 2015 Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
Ana Luiza Chaves Valadão +6 more
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