Toxicology Reports, 2015 Trichothecene mycotoxins, potent translational inhibitors that are associated with human food poisonings and damp-building illnesses, are of considerable concern to animal and human health.
Wenda Wu +3 more
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Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles. [PDF]
PLoS ONE, 2015 Small molecule based therapeutic intervention of amyloids has been limited by their low solubility and poor pharmacokinetic characteristics. We report here, the use of water soluble poly lactic-co-glycolic acid (PLGA)-encapsulated curcumin and emetine ...
Ankit Srivastava +5 more
doaj +3 more sources
Emetine Synergizes with Cisplatin to Enhance Anti-Cancer Efficacy against Lung Cancer Cells [PDF]
International Journal of Molecular Sciences, 2019 Cisplatin is still the primary therapeutic choice for advanced lung cancers without driver mutations. The occurrence of cisplatin resistance is a major clinical problem in lung cancer treatment.
Ti-Hui Wu +5 more
openalex +2 more sources
Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations [PDF]
Virus ResearchThe emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko +24 more
doaj +2 more sources
European Journal of Medicinal Chemistry ReportsThe outbreak of COVID-19 pandemic caused by the infection of SARS-CoV-2, has become a global crisis, threatening public health and disrupting global economy.
Biswanath Dinda +5 more
doaj +2 more sources
CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach [PDF]
Frontiers in NeurologyPurposeGlioma remains a lethal malignancy with limited prognostic biomarkers. This study evaluates the prognostic significance and functional mechanisms of tetraspanin CD9 in glioma to establish its clinical relevance and identify therapeutic strategies ...
Yue Peng +7 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2017 Transcriptional regulation of the multidrug resistance EhPgp5 gene in Entamoeba histolytica is induced by emetine stress. EhPgp5 overexpression alters the chloride-dependent currents that cause trophozoite swelling, diminishing induced programmed cell ...
Alma Nieto +4 more
doaj +2 more sources
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
eLife, 2014 Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies.
Wilson Wong +8 more
doaj +2 more sources
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
Antiviral Research, 2020 Ka-Tim Choy +11 more
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Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study [PDF]
Virology JournalChikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri +6 more
doaj +2 more sources