Results 21 to 30 of about 13,194 (271)
CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach [PDF]
Frontiers in NeurologyPurposeGlioma remains a lethal malignancy with limited prognostic biomarkers. This study evaluates the prognostic significance and functional mechanisms of tetraspanin CD9 in glioma to establish its clinical relevance and identify therapeutic strategies ...
Yue Peng +7 more
doaj +2 more sources
Oncology Report, 2019 Emetine, an amoebicidal drug, exerts potent anticancer activity against various solid tumors, however, the underlying molecular mechanism remains unclear.
Qi Sun +8 more
semanticscholar +3 more sources
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
eLife, 2014 Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies.
Wilson Wong +8 more
doaj +2 more sources
Electrocardiogram after Chloroquine and Emetine [PDF]
Circulation, 1965 Electrocardiographic abnormalities have been studied after administration of chloroquine in 25 patients, of emetine in 28 patients, and of emetine and chloroquine in 28 patients. Abnormalities after chloroquine were less in severity and of shorter duration than after emetine.
B. B. Mathur, L.M. Sanghvi
openaire +4 more sources
Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study [PDF]
Virology JournalChikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri +6 more
doaj +2 more sources
In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2. [PDF]
PLoS ONESevere Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is the causative agent of COVID-19 pandemic, which has resulted in global fatalities since late December 2019.
Mohibullah Shah +11 more
doaj +2 more sources
Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication. [PDF]
FASEB JThe schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Yan Z +11 more
europepmc +2 more sources
Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea. [PDF]
J Cosmet DermatolABSTRACT Background Rosacea is a chronic inflammatory facial disorder with limited therapeutic options, severely impacting patients' quality of life. The identification of druggable genes plays a crucial role in facilitating the development of effective therapeutic strategies.
Deng X, He S, Long H, Xiao J, Xie Z.
europepmc +2 more sources
Cancer Chemotherapy and Pharmacology, 2023 Background Gastric cancer (GC) is a life-threatening malignant tumor with high incidence rate. Despite great progress, there are still many GC sufferers that cannot benefit from the existing anti-GC treatments. Therefore, it is still necessary to develop
Xuerun Peng +5 more
semanticscholar +1 more source