Results 51 to 60 of about 13,194 (271)
Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene [PDF]
, 2001 The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential ...
Attardi, Giuseppe +7 more
core +1 more source
Journal of Infection and Public Health, 2023 Nature has given us yet another wild card in the form of Zika virus (ZIKV). It was found in 1947, but has only recently become an important public health risk, predominantly to pregnant women and their unborn offspring. Currently, no specific therapeutic
Nabeelah Bibi Sadeer +6 more
doaj +1 more source
Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]
, 2017 As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark +11 more
core +2 more sources
PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca2+ Leak in Smooth Muscle Cells
Frontiers in Physiology, 2022 PKC inhibitors stimulate Ca2+ release from internal stores in diverse cell types. Our data indicate that this action cannot be explained by an increased agonist-induced IP3 production or an overloaded SR Ca2+ pool in smooth muscle cells from guinea pig ...
Adan Dagnino-Acosta +1 more
doaj +1 more source
Revista Brasileira de Plantas Medicinais, 2009 Este estudo foi conduzido com 13 populações amostradas nos estados RJ, MG, ES e BA para a coleta de dados ecogeográficos da poaia (Psychotria ipecacuanha).
E.R. Martins +3 more
doaj +1 more source
Very Rare Complementation between Mitochondria Carrying Different Mitochondrial DNA Mutations Points to Intrinsic Genetic Autonomy of the Organelles in Cultured Human Cells [PDF]
, 2000 In the present work, a large scale investigation was done regarding the capacity of cultured human cell lines (carrying in homoplasmic form either the mitochondrial tRNALys A8344G mutation associated with the myoclonic epilepsy and ragged red fiber ...
Attardi, Giuseppe +3 more
core +1 more source
Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice
Molecular Medicine, 2016 Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the pathogenesis of hyperglycemia in NOD murine ...
LaQueta K Hudson +20 more
doaj +1 more source
Identification of Potent EGFR Inhibitors from TCM Database@Taiwan [PDF]
, 2011 Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells.
AE Wakeling +61 more
core +3 more sources
Cell Discovery, 2018 The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need.
Shu Yang +34 more
semanticscholar +1 more source