Results 11 to 20 of about 94,361 (225)

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

open access: yesCancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada   +16 more
wiley   +1 more source

CT Assessment of Subtypes of Pulmonary Emphysema in Mongolian Miners

open access: yesCentral Asian Journal of Medical Sciences, 2020
Objectives: To determine the incidence of subtypes of pulmonary emphysema identified by LDCT imaging and the relationship between emphysema subtypes with smoking and pulmonary function in miners.
Garamjav Khishigdavaa   +7 more
doaj   +1 more source

A circadian based inflammatory response – implications for respiratory disease and treatment

open access: yesSleep Science and Practice, 2017
Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and ...
Maria Comas   +8 more
doaj   +1 more source

Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

open access: yesMolecular Cancer, 2018
Background Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting
Ho Jin Lee   +8 more
doaj   +1 more source

Pulmonary Emphysema: Visual Interpretation and Quantitative Analysis

open access: yes대한영상의학회지, 2021
Pulmonary emphysema is a cause of chronic obstructive pulmonary disease. Emphysema can be accurately diagnosed via CT. The severity of emphysema can be assessed using visual interpretation or quantitative analysis.
Jihang Kim
doaj   +1 more source

Association between plasma sRAGE and emphysema according to the genotypes of AGER gene

open access: yesBMC Pulmonary Medicine, 2022
Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin   +4 more
doaj   +1 more source

Basilar Predominant Emphysema: Thinking beyond Alpha-1-Antitrypsin Deficiency

open access: yesCase Reports in Medicine, 2022
Basilar predominant emphysema, or disproportionate emphysematous involvement of the lung bases compared to the apices, is an uncommon radiographic pattern of emphysema traditionally associated with alpha-1-antitrypsin deficiency (AATD). We present a case
Ho-Man Yeung, Lauren Gaffaney
doaj   +1 more source

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

open access: yesNature Communications, 2016
The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling.
Hye-Jin Boo   +14 more
doaj   +1 more source

S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3‐mediated programmed death‐ligand 1 expression in colorectal cancer

open access: yesClinical and Translational Medicine, 2022
Background Programmed death‐ligand 1 (PD‐L1) has functional roles in cancer stem‐like cell (CSC) phenotypes and chemoresistance besides immune evasion.
Hye‐Young Min   +14 more
doaj   +1 more source

Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. [PDF]

open access: yesPLoS ONE, 2016
To differentiate smoking-related interstitial fibrosis (SRIF) from usual interstitial pneumonia (UIP) with emphysema on CT in combined pulmonary fibrosis and emphysema (CPFE) patients.This study was approved by the institutional review board and informed
Kum Ju Chae   +7 more
doaj   +1 more source

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