Results 11 to 20 of about 231,498 (381)

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.

American Journal of Respiratory and Critical Care Medicine, 2021
INTRODUCTION Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, emphysema, and systemic pathologies.
F. Polverino, T. Wu, J. Rojas-Quintero, Xiaoyun Wang, Jonathan J. Mayo, M. Tomchaney, J. Tram, Samuel E Packard, Duo Zhang, Kristan H Cleveland, E. Córdoba-Lanús, C. Owen, A. Fawzy, G. Kinney, C. Hersh, N. Hansel, Kevin Doubleday, M. Sauler, Y. Tesfaigzi, J. Ledford, C. Casanova, J. Zmijewski, J. Konhilas, P. Langlais, R. Schnellmann, I. Rahman, M. McCormack, B. Celli   +27 more
semanticscholar   +1 more source

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]

, 2016
BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S, Coombs, NA, Elkington, PT, Estepar, RS, Harden, S, Kim, V, Ostridge, K, Staples, KJ, Washko, G, Wilkinson, TM, Williams, N   +10 more
core   +2 more sources

Reversal of emphysema by restoration of pulmonary endothelial cells

Journal of Experimental Medicine, 2021
We tested the role of endothelial dysfunction in the development of COPD/emphysema. We found that restoration of lung endothelial cells and blockade of endothelial-derived leucine-rich α-2-glycoprotein perturbs the pathogenesis of COPD/emphysema.
S. Hisata, A. Racanelli, P. Kermani, Ryan Schreiner, S. Houghton, Brisa Palikuqi, Balvir Kunar, Aiyuan Zhou, K. McConn, Allyson Capili, D. Redmond, D. Nolan, Michael Ginsberg, B. Ding, F. Martinez, J. Scandura, S. Cloonan, S. Rafii, A. Choi   +18 more
semanticscholar   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease

Respiratory Research, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
Patrick He, Ingrid C. Gelissen, Alaina J. Ammit   +2 more
doaj   +1 more source

COVID-19 with spontaneous pneumothorax,pneumomediastinum and subcutaneous emphysema

Journal of Travel Medicine, 2020
Highlight We present a case of COVID-19 pneumonia associated with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema.
Weiyi Wang, R. Gao, Yulu Zheng, Libin Jiang   +3 more
semanticscholar   +1 more source

Pneumomediastinum and subcutaneous emphysema in COVID-19: barotrauma or lung frailty?

ERJ Open Research, 2020
Background In mechanically ventilated acute respiratory distress syndrome (ARDS) patients infected with the novel coronavirus disease (COVID-19), we frequently recognised the development of pneumomediastinum and/or subcutaneous emphysema despite ...
D. Lemmers, M. Abu Hilal, C. Bnà, Chiara Prezioso, E. Cavallo, Niccolò Nencini, S. Crisci, F. Fusina, G. Natalini   +8 more
semanticscholar   +1 more source

Emphysema Is Common in Lungs of Cystic Fibrosis Lung Transplantation Patients: A Histopathological and Computed Tomography Study. [PDF]

PLoS ONE, 2015
Lung disease in cystic fibrosis (CF) involves excessive inflammation, repetitive infections and development of bronchiectasis. Recently, literature on emphysema in CF has emerged, which might become an increasingly important disease component due to the ...
Onno M Mets, Suzan M Roothaan, Inez Bronsveld, Bart Luijk, Ed A van de Graaf, Aryan Vink, Pim A de Jong   +6 more
doaj   +1 more source

Surgery for emphysema [PDF]

BMJ, 2006
Emphysema affects 3.1 million people in the United States alone and causes severe disability and early death in up to 45% of patients.1 Emphysematous destruction of the lung is associated with decreased elastic recoil pressure. As a result, the diseased lung requires less pressure than a normal lung to inflate and, once inflated, exerts less pressure ...
VENUTA, Federico, G. Bognolo
openaire   +3 more sources

Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer

Respiratory Research, 2019
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC ...
Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills, Alaina J. Ammit   +3 more
doaj   +1 more source