Results 11 to 20 of about 219,949 (396)

Emphysema distribution and diffusion capacity predict emphysema progression in human immunodeficiency virus infection [PDF]

PLoS ONE, 2016
Background Chronic obstructive pulmonary disease (COPD) and emphysema are common amongst patients with human immunodeficiency virus (HIV). We sought to determine the clinical factors that are associated with emphysema progression in HIV.
Besutti, Giulia, Dai, Darlene, Guaraldi, Giovanni, Hague, Cameron, Leipsic, Jonathon, Leung, Janice M., Ligabue, Guido, Malagoli, Andrea, Man, S. F. Paul, Santoro, Antonella, Scaglioni, Riccardo, Sin, Don D.   +11 more
core   +4 more sources

Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Respiratory Research, 2019
BackgroundThe mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry, could provide estimates of ...
M. Occhipinti, M. Paoletti, B. Bartholmai, S. Rajagopalan, R. Karwoski, C. Nardi, Riccardo Inchingolo, A. Larici, G. Camiciottoli, F. Lavorini, S. Colagrande, V. Brusasco, M. Pistolesi   +12 more
semanticscholar   +3 more sources

Differentiating Emphysema From Emphysema-Dominated COPD Patients with CT Imaging Feature and Machine Learning. [PDF]

Int J Chron Obstruct Pulmon Dis
Wanjin Guo,1 Mengqi Li,1 Ying Li,2 Xiaole Fan,3 Lei Wu4 1Department of Respiratory and Critical Care Medicine, Shanxi Provincial People’s Hospital, Taiyuan, People’s Republic of China; 2Department of Radiology, Shanxi Provincial People’s Hospital ...
Guo W, Li M, Li Y, Fan X, Wu L.
europepmc   +2 more sources

Emphysema: an ignored radiologic sign of diffuse alveolar hemorrhage. [PDF]

BMC Pediatr
Background Diffuse alveolar hemorrhage (DAH) is characterized by the presence of diffuse ground glass opacities and/or consolidation on chest CT. Emphysema has been reported occasionally.
Lu FC, Wei Q, Li Y, Liu J, Chen X, Li CY, Zeng JJ, Zhang X, Nong GM, Qin YH.   +9 more
europepmc   +2 more sources

Tropomyosin 2.1 collaborates with fibronectin to promote TGF-β1-induced contraction of human lung fibroblasts

Respiratory Research, 2021
Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cellular matrix (ECM).
Peta Bradbury, Cassandra P. Nader, Aylin Cidem, Sandra Rutting, Dianne Sylvester, Patrick He, Maria C. Rezcallah, Geraldine M. O’Neill, Alaina J. Ammit   +8 more
doaj   +1 more source

Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly

Journal of Experimental & Clinical Cancer Research, 2022
Background Cancer stem-like cells (CSCs) play a pivotal role in lung tumor formation and progression. Nerve injury-induced protein 1 (Ninjurin1, Ninj1) has been implicated in lung cancer; however, the pathological role of Ninj1 in the context of lung ...
Seung Yeob Hyun, Hye-Young Min, Ho Jin Lee, Jaebeom Cho, Hye-Jin Boo, Myungkyung Noh, Hyun-Ji Jang, Hyo-Jong Lee, Choon-Sik Park, Jong-Sook Park, Young Kee Shin, Ho-Young Lee   +11 more
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]

, 2016
BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S, Coombs, NA, Elkington, PT, Estepar, RS, Harden, S, Kim, V, Ostridge, K, Staples, KJ, Washko, G, Wilkinson, TM, Williams, N   +10 more
core   +2 more sources

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease

Respiratory Research, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
Patrick He, Ingrid C. Gelissen, Alaina J. Ammit   +2 more
doaj   +1 more source

Emphysema Is Common in Lungs of Cystic Fibrosis Lung Transplantation Patients: A Histopathological and Computed Tomography Study. [PDF]

PLoS ONE, 2015
Lung disease in cystic fibrosis (CF) involves excessive inflammation, repetitive infections and development of bronchiectasis. Recently, literature on emphysema in CF has emerged, which might become an increasingly important disease component due to the ...
Onno M Mets, Suzan M Roothaan, Inez Bronsveld, Bart Luijk, Ed A van de Graaf, Aryan Vink, Pim A de Jong   +6 more
doaj   +1 more source