Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]
, 2016 BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S +10 more
core +2 more sources
Cancer Reports, EarlyView., 2023 Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada +16 more
wiley +1 more source
Automatic Emphysema Detection using Weakly Labeled HRCT Lung Images [PDF]
, 2018 A method for automatically quantifying emphysema regions using High-Resolution Computed Tomography (HRCT) scans of patients with chronic obstructive pulmonary disease (COPD) that does not require manually annotated scans for training is presented.
Carl, Jesper +7 more
core +8 more sources
Subcutaneous emphysema during root canal therapy: endodontic accident by sodium hypoclorite [PDF]
, 2017 Cervicofacial subcutaneous emphysema is defined as the abnormal introduction of air in the subcutaneous tissues of the head and neck. It is mainly caused by trauma, head and neck surgery, general anesthesia, and coughing or habitual performance of ...
Battisti, Andrea +5 more
core +1 more source
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Signal Transduction and Targeted Therapy, 2023 Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu +14 more
doaj +1 more source
Association Between Air Pollution and Lung Lobar Emphysema in COPD
Frontiers in Medicine, 2021 The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear.
Nguyen Thanh Tung +22 more
doaj +1 more source
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]
, 2011 Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong +4 more
core +1 more source
CT Assessment of Subtypes of Pulmonary Emphysema in Mongolian Miners
Central Asian Journal of Medical Sciences, 2020 Objectives: To determine the incidence of subtypes of pulmonary emphysema identified by LDCT imaging and the relationship between emphysema subtypes with smoking and pulmonary function in miners.
Garamjav Khishigdavaa +7 more
doaj +1 more source
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core +2 more sources
A circadian based inflammatory response – implications for respiratory disease and treatment
Sleep Science and Practice, 2017 Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and ...
Maria Comas +8 more
doaj +1 more source