Results 51 to 60 of about 588,275 (307)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Telaah Komitmen Organisasi: Pengaruh Atas Penilaian Kinerja, Perencanaan Karier dan Partisipasi Karyawan

Jurnal Aplikasi Bisnis dan Manajemen, 2022
Much empiric research had been conducted on the antecedents of employee organizational commitment. However, there is still less research that examines the effect of HR management praxis, such as performance appraisal systems, career planning systems, and
Silvy Sondari Gadzali
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

PENGARUH KEPUASAN KERJA DAN IKLIM ORGANISASI TERHADAP KOMITMEN PEGAWAI DAN DAMPAKNYA PADA KINERJA PEGAWAI DINAS PENDAPATAN DAN KEKAYAAN ACEH [PDF]

, 2014
The purpose of this study was to determine: (1) job satisfaction, and organizational climate either simultaneously or partially on employee commitment (2) the effect of job satisfaction and organizational climate either simultaneously or partially on ...
SAFRI
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

How does trust in leader influences organizational commitment? A test of a moderated mediation model

Acta Psychologica
This study examines the link between trust in leader, employee silence, and affective, normative, and continuance organizational commitment. Additionally, this study analyzes how employee silence mediates the link between trust in leader and ...
Savita S Rai, Navin Kumar Koodamara
doaj   +1 more source

THE ROLE OF PERSONALITY ASPECTS AND EMPLOYEE COMMITMENTS AS AM EFFORT TO MAXIMIZE WORK PERFORMANCE

Jurnal Aplikasi Manajemen, 2022
This study presents a model that links work performance, leadership behavior, personality, and work commitment. The main objective is to investigate the direct and indirect effects of personality, work commitment, and leadership behavior on work ...
Abimanyu Tuwuh Sembhodo, Adya Hermawati, Sodik Sodik, Syamsul Bahri, Syahruddin Syahruddin, Shujahat Ali   +5 more
doaj   +1 more source

Faktor-Faktor Yang Mempengaruhi Komitmen Kerja Karyawan (Studi Kasus di PT. Pos Surakarta) [PDF]

, 2018
This study aims to determine: (1) The influence of personal factors on employees' commitment to PT. Surakarta post, (2) Influence of role related to employee commitment at PT. Surakarta post, (3) The influence of work experience on employee commitment to
, Muzakar Isa, SE., M.Si.,, Johan Saputra, Muhammad   +1 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Pengaruh Komitmen Pegawai dan Kepuasan Kerja terhadap Disiplin Kerja di Kantor Badan Penelitian dan Pengembangan Provinsi Riau [PDF]

, 2014
The aims of this research is to find out the employee commitment and job satisfaction with work discipline. The population of this research is taken from employes of Research and Development of Riau Province Offices.
Hasbi, M. I. (Muhammad), Pramadewi, A. (Arwinence)   +1 more
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